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Molecular interactions between the main components of Shuanghuanglian injection and ciprofloxacin injection based on self-assembly
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Jiang-ling LI1, Shuang LIU2, 3, Yi-qing XIE4, Jiang-lan LONG2, 3, Zhen-zhen WANG2, 3, Ai-ting WANG2, 3, *, Qiang MA4, *, Dan YAN2, 3, *
Acta Pharmaceutica Sinica | 2022, 57(8) : 2445 - 2452
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Acta Pharmaceutica Sinica | 2022, 57(8): 2445-2452
• Original Articles •
Molecular interactions between the main components of Shuanghuanglian injection and ciprofloxacin injection based on self-assembly
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Jiang-ling LI1, Shuang LIU2, 3, Yi-qing XIE4, Jiang-lan LONG2, 3, Zhen-zhen WANG2, 3, Ai-ting WANG2, 3, *, Qiang MA4, *, Dan YAN2, 3, *
Affiliations
  • 1. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 2. Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • 3. Beijing Institute of Clinical Pharmacy, Beijing 100050, China
  • 4. Chinese Academy of Inspection and Quarantine, Beijing 100176, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0696
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The combination of Shuanghuanglian injection (SHLI) and ciprofloxacin injection (CIPI) is frequently prescribed in clinical practice, but the basis for the combination is weak. In this study, isothermal titration calorimetry and ultraviolet-visible absorption spectrometry were applied to identify the molecular interactions of SHLI and its main components, chlorogenic acid and neochlorogenic acid with CIPI. Scanning electron microscopy, Fourier-transform infrared spectroscopy, and cold-spray ionization mass spectrometry were performed to confirm that this molecular interaction was related to the formation of self-assembled supramolecular systems induced by chlorogenic acid and neochlorogenic acid with CIPI through weak intermolecular bonds. The antibacterial activity toward Pseudomonas aeruginosa (P. aeruginosa) was evaluated via molecular interactions, and the inhibitory ability of SHLI, chlorogenic acid and neochlorogenic acid against P. aeruginosa was significantly reduced after interaction with CIPI. A molecular docking study demonstrated that the reduced antibacterial ability was closely related to the competitive binding of drug molecules to the same binding site of the DNA gyrase B (GyrB) subunit of P. aeruginosa. The present study uncovered the intermolecular interactions of SHLI and its main components chlorogenic acid and neochlorogenic acid with CIPI from the perspective of molecular self-assembly and contribute to the reduction of its antibacterial ability, providing a basis for the clinical combination of SHLI and CIPI.

Shuanghuanglian injection  /  ciprofloxacin injection  /  self-assembly  /  molecular interaction  /  antibacterial effect
Jiang-ling LI, Shuang LIU, Yi-qing XIE, Jiang-lan LONG, Zhen-zhen WANG, Ai-ting WANG, Qiang MA, Dan YAN. Molecular interactions between the main components of Shuanghuanglian injection and ciprofloxacin injection based on self-assembly[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2445 -2452 . DOI: 10.16438/j.0513-4870.2022-0696
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Year 2022 volume 57 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2022-0696
  • Receive Date：2022-06-06
  • Online Date：2025-12-23
  • Published：2022-08-12
Article Data
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History
  • Received：2022-06-06
  • Revised：2022-06-22
Funding
Affiliations
    1. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    2. Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    3. Beijing Institute of Clinical Pharmacy, Beijing 100050, China
    4. Chinese Academy of Inspection and Quarantine, Beijing 100176, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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