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A new isocoumarin from a starfish-associated fungus Aspergillus sp. WXF1904
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Ling-ling WANG1, Da GUAN1, 2, Xiao-fang WANG4, Xiao-yan PANG2, Yong-hong LIU2, 3, *, Xiu-ping LIN2, 3, *
Acta Pharmaceutica Sinica | 2022, 57(11) : 3356 - 3360
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Acta Pharmaceutica Sinica | 2022, 57(11): 3356-3360
• Original Articles •
A new isocoumarin from a starfish-associated fungus Aspergillus sp. WXF1904
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Ling-ling WANG1, Da GUAN1, 2, Xiao-fang WANG4, Xiao-yan PANG2, Yong-hong LIU2, 3, *, Xiu-ping LIN2, 3, *
Affiliations
  • 1. Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China
  • 2. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
  • 3. Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou), Guangzhou 511458, China
  • 4. Marine Environmental Engineering Center, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Published: 2022-11-12 doi: 10.16438/j.0513-4870.2022-0577
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A fungal strain WXF1904, was isolated from a starfish sample corrected in the South China Sea. According to its internal transcribed spacer (ITS) analysis, the strain was identified as a member of the genus Aspergillus and designated as Aspergillus sp. WXF1904. One new isocoumarin containing halogennamed 6-chloro-5, 7-dihydroxy-3, 8-dimethylisocoumarin (1), along with six known compounds pilobolusate (2), p-hydroxybenzaldehyde (3), methyl orsellinate (4), catechol (5), vanillic acid (6), and wasabidienone E (7), were isolated from the cultures of Aspergillus sp. WXF1904 by silica gel column chromatography, ODS gel column chromatography, and high performance liquid chromatography (HPLC). Their structures were elucidated by high resolution mass spectrometry (HR-MS), nuclear magnetic resonance (NMR) as well as literature comparison. The new compound 5-chloro-6, 7-dihydroxy-3, 8-dimethylisocoumarin and compound 2 showed weak acetylcholinesterase inhibitory activity.

starfish-associated fungus  /  Aspergillus sp. WXF1904  /  secondary metabolite  /  isocoumarin  /  acetylcholinesterase inhibitory activity
Ling-ling WANG, Da GUAN, Xiao-fang WANG, Xiao-yan PANG, Yong-hong LIU, Xiu-ping LIN. A new isocoumarin from a starfish-associated fungus Aspergillus sp. WXF1904[J]. Acta Pharmaceutica Sinica, 2022 , 57 (11) : 3356 -3360 . DOI: 10.16438/j.0513-4870.2022-0577
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Year 2022 volume 57 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2022-0577
  • Receive Date：2022-05-12
  • Online Date：2025-12-24
  • Published：2022-11-12
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History
  • Received：2022-05-12
  • Revised：2022-07-19
Funding
Affiliations
    1. Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China
    2. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
    3. Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou), Guangzhou 511458, China
    4. Marine Environmental Engineering Center, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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