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Role of dexamethasone/captopril co-loaded immunoliposome-nanoparticle hybrids on the regulation of macrophage polarization in mice with glomerulonephritis
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Xian-zhe LI1, Liu-ting ZHOU2, Yue ZHAO3, Tian-qing LIU4, Hong-mei LIU1, Li-li HE1, Zhi-xiang YUAN1, Lu HAN1, 5, *
Acta Pharmaceutica Sinica | 2022, 57(8) : 2388 - 2398
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Acta Pharmaceutica Sinica | 2022, 57(8): 2388-2398
• Original Articles •
Role of dexamethasone/captopril co-loaded immunoliposome-nanoparticle hybrids on the regulation of macrophage polarization in mice with glomerulonephritis
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Xian-zhe LI1, Liu-ting ZHOU2, Yue ZHAO3, Tian-qing LIU4, Hong-mei LIU1, Li-li HE1, Zhi-xiang YUAN1, Lu HAN1, 5, *
Affiliations
  • 1. College of Pharmacy, Southwest Minzu University, Chengdu 610225, China
  • 2. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611134, China
  • 3. Department of Pharmacy, Sichuan Tianfu New Area People's Hospital, Chengdu 610213, China
  • 4. Queensland Institute of Medical Research, Herston 4006, Australia
  • 5. Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Chengdu 610041, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0568
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In this study, dexamethasone (DXMS) and captopril (CAP) were co-loaded into poly(lactic-co-glycolic acid) (PLGA) nanoparticles with a surface coating of a phospholipid bilayer, and then the core-shell nanoparticles were modified with polyethylene glycol and integrin α8 antibody to obtain immunoliposome-nanoparticle hybrids (DXMS/CAP@PLGA-ILs). The role of nanoparticles on the renal targeting, anti-inflammatory effects, and macrophage differentiation were investigated. The results showed that the particle size of the nanoparticles was 115.9 ± 2.89 nm, and the core-shell structure could be observed under an electron microscope. The drug loading capacity of DXMS and CAP was 5.72% ± 0.37% and 7.51% ± 0.07%, respectively. The results of in vitro experiments showed that DXMS/CAP@PLGA-ILs could reduce the secretion of specific cytokines and the mRNA expression of markers in M2-type macrophages, thus promoting the differentiation of M2-type macrophages in the direction of unpolarized macrophages. In vivo experiments in mice showed that DXMS/CAP@PLGA-ILs had a significant renal targeting effect, which could restore the renal index, serum creatinine, and urea nitrogen levels of mesangial proliferative glomerulonephritis in mice. Moreover, DXMS/CAP@PLGA-ILs could reduce both the secretion of inflammatory cytokines and the mRNA expression levels of M1 and M2 macrophage markers in the kidney. All the animal experiments were in accordance with the regulations of Animal Ethics Committee of Sichuan Agricultural University. In conclusion, renal-targeting DXMS/CAP@PLGA-ILs could effectively regulate the polarization of macrophages and had an "anti-inflammatory/anti-fibrosis" therapeutic effect, providing a new strategy and basis for the targeted therapy of glomerulonephritis.

glomerulonephritis  /  macrophage polarization  /  renal targeting  /  dexamethasone  /  captopril
Xian-zhe LI, Liu-ting ZHOU, Yue ZHAO, Tian-qing LIU, Hong-mei LIU, Li-li HE, Zhi-xiang YUAN, Lu HAN. Role of dexamethasone/captopril co-loaded immunoliposome-nanoparticle hybrids on the regulation of macrophage polarization in mice with glomerulonephritis[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2388 -2398 . DOI: 10.16438/j.0513-4870.2022-0568
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Year 2022 volume 57 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2022-0568
  • Receive Date：2022-05-11
  • Online Date：2025-12-23
  • Published：2022-08-12
Article Data
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History
  • Received：2022-05-11
  • Revised：2022-06-20
Funding
Affiliations
    1. College of Pharmacy, Southwest Minzu University, Chengdu 610225, China
    2. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611134, China
    3. Department of Pharmacy, Sichuan Tianfu New Area People's Hospital, Chengdu 610213, China
    4. Queensland Institute of Medical Research, Herston 4006, Australia
    5. Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Chengdu 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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