Home Journals Articles Updates About
CN
image
收藏切换
Metabolites of schaftoside in mouse plasma, bile, urine and feces after oral administration by UPLC-Q/TOF-MS/MS
收藏切换
PDF
Ya-qin WEI1, Tian-yun WANG2, Ya-ting LI1, Yu-lang CHEN1, 2, Wen-xing LIAO1, Yan DU1, Dao-quan TANG1, *
Acta Pharmaceutica Sinica | 2022, 57(9) : 2811 - 2820
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(9): 2811-2820
• Original Articles •
Metabolites of schaftoside in mouse plasma, bile, urine and feces after oral administration by UPLC-Q/TOF-MS/MS
Full
Ya-qin WEI1, Tian-yun WANG2, Ya-ting LI1, Yu-lang CHEN1, 2, Wen-xing LIAO1, Yan DU1, Dao-quan TANG1, *
Affiliations
  • 1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
  • 2. Huai'an Hosipital of Huai'an City, Huai'an 223200, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0436
Outline
收藏切换

Ultra-high performance liquid chromatography coupled with quadrupole/time-of-flight tandem mass spectrometry (UPLC-Q/TOF-MS/MS) has been used to detect the metabolites of schaftoside in plasma, bile, urine and feces of mice after oral administration. The study was approved by the Experimental Animal Ethics Committee from Xuzhou Medical University (No. XZMULL201612024). Compounds were identified by analyzing their high-resolution mass spectrometry data, mass spectra, and comparison with reference substances and the literatures. The parent compound and 29 metabolites were detected in the plasma, bile, urine and feces samples of mice. The main metabolic pathways of schaftoside in mice include deglycosylation/glycosylation, hydroxylation/dehydroxylation, hydrogenation, methylation, acetylation, sulfation, and glucuronidation. This study provides references for the material basis of schaftoside in vivo.

schaftoside  /  mouse  /  parent compound  /  metabolite  /  UPLC-Q/TOF-MS/MS
Ya-qin WEI, Tian-yun WANG, Ya-ting LI, Yu-lang CHEN, Wen-xing LIAO, Yan DU, Dao-quan TANG. Metabolites of schaftoside in mouse plasma, bile, urine and feces after oral administration by UPLC-Q/TOF-MS/MS[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2811 -2820 . DOI: 10.16438/j.0513-4870.2022-0436
Appendix
Less
Year 2022 volume 57 Issue 9
PDF
192
76
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0436
  • Receive Date：2022-04-14
  • Online Date：2025-12-24
  • Published：2022-09-12
Article Data
Affiliations
History
  • Received：2022-04-14
  • Revised：2022-06-27
Funding
Affiliations
    1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
    2. Huai'an Hosipital of Huai'an City, Huai'an 223200, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0436
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House