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Research progress on pharmacological effects and clinical combined application of 3-n-butylphthalide in cerebrovascular diseases
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Wen-juan NI1, Wei-xia LI2, *, Xiao-yan WANG2, Ya-li WU2, Bing HAN1, Jin-hao JIA1, Kun LI1, Qiu-ru JI1, Jin-fa TANG2, *
Acta Pharmaceutica Sinica | 2022, 57(10) : 3047 - 3056
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Acta Pharmaceutica Sinica | 2022, 57(10): 3047-3056
• Special Reports Ⅱ: Traditional Chinese Medicine in the Prevention and Treatment of Cardio-cerebrovascular Related Diseases •
Research progress on pharmacological effects and clinical combined application of 3-n-butylphthalide in cerebrovascular diseases
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Wen-juan NI1, Wei-xia LI2, *, Xiao-yan WANG2, Ya-li WU2, Bing HAN1, Jin-hao JIA1, Kun LI1, Qiu-ru JI1, Jin-fa TANG2, *
Affiliations
  • 1. Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Henan Province Engineering Research Center of Clinical Application, Evaluation and Transformation of Traditional Chinese Medicine, Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
Published: 2022-10-12 doi: 10.16438/j.0513-4870.2022-0366
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Cerebrovascular diseases have the characteristics of high morbidity, high disability, high mortality and high recurrence rate, which seriously harm human health and increase the national health economic burden. 3-n-Butylphthalide (NBP) is a new drug commonly used in clinical treatment of cerebrovascular diseases, and it is also one of the main active components in traditional Chinese medicine such as Angelica sinensis and Chuanxiong. In this review, the pharmacological effects of NBP were systematically summarized. Studies have shown that NBP has pharmacological effects such as antiplatelet aggregation, anti-thrombosis, inhibiting neuronal apoptosis, anti-oxidation, anti-cerebral ischemia, anti-brain injury, and anti-vascular dementia. In clinical practice, it is often combined with edaravone, alteplase, fasudil, Xingnaojing injection, and compound Danshen injection to treat cerebral vascular diseases such as stroke, vascular dementia, and cerebral vasospasm, and plays a good synergistic effect. This summary could provide support for the rational clinical application of NBP, and also provide basis for the in-depth study of the interaction of its drug combination.

3-n-butylphthalide  /  cerebrovascular disease  /  pharmacological action  /  clinical combined application
Wen-juan NI, Wei-xia LI, Xiao-yan WANG, Ya-li WU, Bing HAN, Jin-hao JIA, Kun LI, Qiu-ru JI, Jin-fa TANG. Research progress on pharmacological effects and clinical combined application of 3-n-butylphthalide in cerebrovascular diseases[J]. Acta Pharmaceutica Sinica, 2022 , 57 (10) : 3047 -3056 . DOI: 10.16438/j.0513-4870.2022-0366
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doi: 10.16438/j.0513-4870.2022-0366
  • Receive Date：2022-08-25
  • Online Date：2025-12-24
  • Published：2022-10-12
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  • Received：2022-08-25
  • Revised：2022-09-08
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Affiliations
    1. Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Henan Province Engineering Research Center of Clinical Application, Evaluation and Transformation of Traditional Chinese Medicine, Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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