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The research advance on subtypes and relevant therapy of Parkinson's disease
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De-wen KONG1, Li-da DU2, Nan JIANG1, 3, Hai-guang YANG1, Lian-hua FANG1, *, Guan-hua DU1, *
Acta Pharmaceutica Sinica | 2022, 57(8) : 2245 - 2252
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Acta Pharmaceutica Sinica | 2022, 57(8): 2245-2252
• Reviews •
The research advance on subtypes and relevant therapy of Parkinson's disease
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De-wen KONG1, Li-da DU2, Nan JIANG1, 3, Hai-guang YANG1, Lian-hua FANG1, *, Guan-hua DU1, *
Affiliations
  • 1. Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Department of Surgery, University of Toronto, Toronto M5S1A8, Canada
  • 3. School of Pharmacy, Henan University, Kaifeng 475004, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0355
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Parkinson's disease (PD) is a progressive neurodegenerative disease with a high clinical heterogeneity. According to its motor symptoms, PD patients are divided into predominant tremor-dominant, postural instability and gait difficulty-dominant/akinetic-rigid and mixed subtypes. Different subtypes show different prognostic characteristics and different sensitivities to drugs. Therefore, the early classification of PD is of great significance for the treatment and prognosis of the disease. This paper reviews the clinical classification methods of different subtypes of PD, summarizes the latest biochemical markers and imaging features, and analyzed the differences in incidence, prognosis and pathological mechanism. The current clinical treatment drugs and methods have been preliminarily targeted for treatment based on PD classification, and there are many animal models of PD subtypes have been studied, providing new methods and strategies for mechanism research and preclinical pharmacodynamics evaluation of PD subtypes.

Parkinson's disease  /  subtype  /  biomarker  /  prognosis  /  pathology  /  therapy
De-wen KONG, Li-da DU, Nan JIANG, Hai-guang YANG, Lian-hua FANG, Guan-hua DU. The research advance on subtypes and relevant therapy of Parkinson's disease[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2245 -2252 . DOI: 10.16438/j.0513-4870.2022-0355
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Article Info
doi: 10.16438/j.0513-4870.2022-0355
  • Receive Date：2022-03-28
  • Online Date：2025-12-23
  • Published：2022-08-12
Article Data
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History
  • Received：2022-03-28
  • Revised：2022-04-26
Funding
Affiliations
    1. Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Department of Surgery, University of Toronto, Toronto M5S1A8, Canada
    3. School of Pharmacy, Henan University, Kaifeng 475004, China
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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