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The recent advance of direct anti-HBV drug candidates in clinical trials
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Mei WANG1, Lin-yue LIU1, Chuan-ju LI1, Jun LIU2, *, Hai-yong JIA1, *
Acta Pharmaceutica Sinica | 2022, 57(10) : 2972 - 2984
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Acta Pharmaceutica Sinica | 2022, 57(10): 2972-2984
• Special Reports Ⅰ: New Targets, New Strategies for Drug Discovery and Advances in Antiviral Drug Research •
The recent advance of direct anti-HBV drug candidates in clinical trials
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Mei WANG1, Lin-yue LIU1, Chuan-ju LI1, Jun LIU2, *, Hai-yong JIA1, *
Affiliations
  • 1. School of Pharmacy, Weifang Medical University, Weifang 261053, China
  • 2. School of Nursing, Weifang Medical University, Weifang 261053, China
Published: 2022-10-12 doi: 10.16438/j.0513-4870.2022-0318
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Hepatitis B virus (HBV) infection is a serious global public health problem. Chronic hepatitis B virus infection can cause health problems such as cirrhosis, liver metabolism disorders and hepatocellular carcinoma. Nucloes(t)ide analogues and interferon drugs used to treat chronic HBV infection do not completely eradicate covalently closed circular DNA (cccDNA) and integrated genome of HBV DNA, so that they cannot achieve the functional cure of chronic HBV infection. Currently, a series of drugs targeting the phases of HBV lifecycle and immunomodulators have entered clinical trials. Here, we review the current status of the therapeutic drugs as well as the recent advance of direct antiviral agents.

hepatitis B virus  /  drug target  /  nucloes(t)ide analogue  /  direct antiviral agent
Mei WANG, Lin-yue LIU, Chuan-ju LI, Jun LIU, Hai-yong JIA. The recent advance of direct anti-HBV drug candidates in clinical trials[J]. Acta Pharmaceutica Sinica, 2022 , 57 (10) : 2972 -2984 . DOI: 10.16438/j.0513-4870.2022-0318
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Year 2022 volume 57 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2022-0318
  • Receive Date：2022-03-15
  • Online Date：2025-12-24
  • Published：2022-10-12
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History
  • Received：2022-03-15
  • Revised：2022-04-08
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Affiliations
    1. School of Pharmacy, Weifang Medical University, Weifang 261053, China
    2. School of Nursing, Weifang Medical University, Weifang 261053, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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