Home Journals Articles Updates About
CN
image
收藏切换
Research progress on the regulation and mechanism of reactive oxygen species on tumor immune checkpoints
收藏切换
PDF
Xiao-feng LI1, Yuan WANG2, Shu-ying WEI2, Wei ZOU2, Xin LUO2, Jia-yi LI2, Zhong-hong WEI2, Su-yun YU2, Xiao-man LI2, Wen-xing CHEN2, Ai-yun WANG2, Yang ZHAO1, Yin LU2, 3, 4, Yuan-yuan WU2, *
Acta Pharmaceutica Sinica | 2022, 57(6) : 1565 - 1573
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(6): 1565-1573
• Special Reports: Oxidative Stress in Physiopathology and Pharmacological Treatment •
Research progress on the regulation and mechanism of reactive oxygen species on tumor immune checkpoints
Full
Xiao-feng LI1, Yuan WANG2, Shu-ying WEI2, Wei ZOU2, Xin LUO2, Jia-yi LI2, Zhong-hong WEI2, Su-yun YU2, Xiao-man LI2, Wen-xing CHEN2, Ai-yun WANG2, Yang ZHAO1, Yin LU2, 3, 4, Yuan-yuan WU2, *
Affiliations
  • 1. School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. Jiangsu International Cooperative Laboratory of Traditional Chinese Medicine and Regenerative Medicine Research, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 4. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2022-0269
Outline
收藏切换

Immune checkpoints (ICs) are immunosuppressive molecules expressed on immune cells, which can regulate immune cells' activation. Immune checkpoint inhibitors (ICIs) which can block the interaction of immune checkpoints and their ligands, improve the cytotoxic effect of the immune system on tumor cells. Immunotherapy such as employing ICIs has gradually become a conventional therapeutic strategy for cancer treatment. However, the low response rate and the emergence of drug resistance have seriously affected the clinical efficacy of ICIs. Reactive oxygen species (ROS) are electronic reduction products of active oxygen, as well as natural by-products of cell metabolism, which can be used as regulators of intercellular signals. Tumor microenvironment (TME) is often in the state of oxidative stress (OS), which is the imbalance between oxidative system and antioxidant system. ROS can affect the interaction with its ligands by regulating the expression and activity of immune checkpoints in TME, thus affecting the anti-tumor effect of immune cells. Accumulating studies have shown that ROS could regulate tumor immune checkpoints through several pathways. Due to different types and stages of tumor, it would be clinical beneficial to understand the mechanistic link of ROS on tumor immune checkpoint, and choose appropriate ROS regulators combined with immune checkpoint inhibitors to maximize anti-tumor effects. This article reviews the common metabolic sources and characteristics of ROS, the regulatory effect and mechanism of ROS on tumor immune checkpoints and its therapeutic application.

reactive oxygen species  /  oxidative stress  /  immune checkpoint  /  tumor microenvironment  /  action mechanism
Xiao-feng LI, Yuan WANG, Shu-ying WEI, Wei ZOU, Xin LUO, Jia-yi LI, Zhong-hong WEI, Su-yun YU, Xiao-man LI, Wen-xing CHEN, Ai-yun WANG, Yang ZHAO, Yin LU, Yuan-yuan WU. Research progress on the regulation and mechanism of reactive oxygen species on tumor immune checkpoints[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1565 -1573 . DOI: 10.16438/j.0513-4870.2022-0269
Appendix
Less
Year 2022 volume 57 Issue 6
PDF
169
73
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0269
  • Receive Date：2022-02-28
  • Online Date：2025-12-23
  • Published：2022-06-12
Article Data
Affiliations
History
  • Received：2022-02-28
  • Revised：2022-04-28
Funding
Affiliations
    1. School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. Jiangsu International Cooperative Laboratory of Traditional Chinese Medicine and Regenerative Medicine Research, Nanjing University of Chinese Medicine, Nanjing 210023, China
    4. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0269
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House