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Research advances of small molecule inhibitors in the treatment of mixed lineage leukemia
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Meng-lan LUO1, 2, Yu-ting CHEN2, Tong-chao LIU2, Yong-mei CUI*, 1, Dan-qi CHEN*, 2, Bing XIONG*, 2
Acta Pharmaceutica Sinica | 2022, 57(8) : 2292 - 2312
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Acta Pharmaceutica Sinica | 2022, 57(8): 2292-2312
• Reviews •
Research advances of small molecule inhibitors in the treatment of mixed lineage leukemia
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Meng-lan LUO1, 2, Yu-ting CHEN2, Tong-chao LIU2, Yong-mei CUI*, 1, Dan-qi CHEN*, 2, Bing XIONG*, 2
Affiliations
  • 1. College of Sciences, Shanghai University, Shanghai 200444, China
  • 2. University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai Institute of Materia Medica, Shanghai 201203, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0236
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Acute leukemia (AL) is a kind of malignant clonal disease of hematopoietic stem cells. Rearrangement of mixed lineage leukemia (MLL) gene can be observed in about 5%-10% of AL patients. Currently, AL patients with MLL-rearrangements (MLL-r) lack effective treatment and are usually associated with poor prognoses. Recent studies have shown that many epigenetic regulators are directly or indirectly involved in the occurrence and development of AL carrying MLL-r (MLL), which provides a biological basis for the use of epigenetic regulation strategies to treat MLL. In this review, we start from the epigenetic regulation mechanism of MLL, and select representative drug targets to briefly analyze the relationship between each target and MLL and summarize the development progress of their inhibitors, hoping to provide reference for the subsequent research and development of drugs for the treatment of MLL.

mixed lineage leukemia  /  mixed lineage leukemia fusion protein  /  epigenetic regulator  /  inhibitor
Meng-lan LUO, Yu-ting CHEN, Tong-chao LIU, Yong-mei CUI, Dan-qi CHEN, Bing XIONG. Research advances of small molecule inhibitors in the treatment of mixed lineage leukemia[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2292 -2312 . DOI: 10.16438/j.0513-4870.2022-0236
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Year 2022 volume 57 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2022-0236
  • Receive Date：2022-02-24
  • Online Date：2025-12-23
  • Published：2022-08-12
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  • Received：2022-02-24
  • Revised：2022-03-15
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Affiliations
    1. College of Sciences, Shanghai University, Shanghai 200444, China
    2. University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai Institute of Materia Medica, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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