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Research progress in clinical treatment of Alzheimer's disease and potential drugs from natural products
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Ping ZHANG1, Hui JI2, Qing-hua HU2, *
Acta Pharmaceutica Sinica | 2022, 57(7) : 1954 - 1961
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Acta Pharmaceutica Sinica | 2022, 57(7): 1954-1961
• Reviews •
Research progress in clinical treatment of Alzheimer's disease and potential drugs from natural products
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Ping ZHANG1, Hui JI2, Qing-hua HU2, *
Affiliations
  • 1. Zhongshan Vocational College, Nanjing 210049, China
  • 2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Published: 2022-07-12 doi: 10.16438/j.0513-4870.2022-0226
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With the acceleration of the aging process of our country's population, the impact of aging-related diseases - Alzheimer's disease (AD) on society and families has become increasingly prominent. AD is caused by multiple mechanisms, and the pathogenesis has not been fully elucidated. Most of the clinical treatments are single therapy, which mainly focuses on improving symptoms and are difficult to reverse the disease process. Therefore, the development of drugs that can both improve symptoms and reverse the disease process is extremely urgent in clinical. Increasing number of studies has shown that traditional Chinese medicine plays an important role in the prevention and treatment of AD. The natural products have many advantages, such as novel structures, multiple targets and diverse activities, which can be used as an important source of leading compounds for the treatment of AD. The review summarizes the main clinical treatment methods and the research progress of natural ingredients in traditional Chinese medicine, and provides a reference for the follow-up clinical treatment of AD combined with the advantages of traditional Chinese medicine treatment.

Alzheimer's disease  /  amyloid-β protein  /  Tau protein  /  traditional Chinese medicine  /  natural product
Ping ZHANG, Hui JI, Qing-hua HU. Research progress in clinical treatment of Alzheimer's disease and potential drugs from natural products[J]. Acta Pharmaceutica Sinica, 2022 , 57 (7) : 1954 -1961 . DOI: 10.16438/j.0513-4870.2022-0226
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Year 2022 volume 57 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2022-0226
  • Receive Date：2022-02-21
  • Online Date：2025-12-23
  • Published：2022-07-12
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History
  • Received：2022-02-21
  • Revised：2022-03-12
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Affiliations
    1. Zhongshan Vocational College, Nanjing 210049, China
    2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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