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Analysis of COVID-19 vaccine products and technologies by oral route
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Hua GE, Li-yong JIANG, Shu Liu, Tian-xi Diao*
Acta Pharmaceutica Sinica | 2022, 57(4) : 845 - 853
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Acta Pharmaceutica Sinica | 2022, 57(4): 845-853
• Anti Novel Coronavirus Drugs Research •
Analysis of COVID-19 vaccine products and technologies by oral route
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Hua GE, Li-yong JIANG, Shu Liu, Tian-xi Diao*
Affiliations
  • Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2022-0104
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Coronavirus disease 2019 (COVID-19) continues to be prevalent all over the world and mutant strains are constantly appearing, the application of vaccine is still an important method of epidemic prevention and control. Mucosal immunity plays an important role in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invasion. The currently marketed injectable COVID-19 vaccine mainly activates humoral immunity, but it is difficult to induce effective mucosal immunity, and it is unable to prevent pathogen invasion in the early stage of virus infection. Compared with injection vaccination, inoculation of the COVID-19 vaccine through mucosal routes such as nasal or oral can closely imitate the natural infection pathway of the virus and induce a comprehensive immune response. It is an ideal choice for rapid and extensive vaccination because it has the advantages of simple and convenient use, easy to achieve self-management of vaccinators, reduced demand for professional medical personnel and so on. In this paper, we summarized and analyzed the products and technical platforms of COVID-19 vaccine inoculated by oral route, in order to provide reference for related research work.

mucosal immunity  /  oral route  /  COVID-19 vaccine  /  technical analysis
Hua GE, Li-yong JIANG, Shu Liu, Tian-xi Diao. Analysis of COVID-19 vaccine products and technologies by oral route[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 845 -853 . DOI: 10.16438/j.0513-4870.2022-0104
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doi: 10.16438/j.0513-4870.2022-0104
  • Receive Date：2022-01-25
  • Online Date：2025-12-22
  • Published：2022-04-12
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History
  • Received：2022-01-25
  • Revised：2022-02-25
Affiliations
    Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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