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Potential role of brain cell senescence in the pathogenesis of Alzheimer's disease
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Yu-xin LIU1, 2, 3, Xue-mei QIN1, 2, 3, *, Li GAO1, 2, 3, *
Acta Pharmaceutica Sinica | 2022, 57(7) : 1946 - 1953
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Acta Pharmaceutica Sinica | 2022, 57(7): 1946-1953
• Reviews •
Potential role of brain cell senescence in the pathogenesis of Alzheimer's disease
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Yu-xin LIU1, 2, 3, Xue-mei QIN1, 2, 3, *, Li GAO1, 2, 3, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
  • 3. The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan 030006, China
Published: 2022-07-12 doi: 10.16438/j.0513-4870.2021-1869
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Cell senescence is characterized by permanent cell cycle arrest, accompanied by the changes in cell metabolism and epigenetic regulation. Alzheimer's disease (AD) is a common neurodegenerative disease, with the main symptoms of memory loss and cognitive impairment. A large number of studies have shown that the senescence of central nervous system cells such as astrocytes and microglia is closely related to the occurrence of AD. Inhibition of brain cell senescence is expected to provide new ideas and therapeutic strategies for the prevention and treatment of AD. This paper reviews the potential roles and mechanisms of senescence of brain cells in AD, and interaction effects among brain cells. This review will provide a new direction for the study of pathological mechanism of AD and the development of anti-AD drugs.

Alzheimer's disease  /  cognitive impairment  /  cell senescence  /  astrocyte  /  microglia
Yu-xin LIU, Xue-mei QIN, Li GAO. Potential role of brain cell senescence in the pathogenesis of Alzheimer's disease[J]. Acta Pharmaceutica Sinica, 2022 , 57 (7) : 1946 -1953 . DOI: 10.16438/j.0513-4870.2021-1869
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doi: 10.16438/j.0513-4870.2021-1869
  • Receive Date：2021-12-30
  • Online Date：2025-12-23
  • Published：2022-07-12
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History
  • Received：2021-12-30
  • Revised：2022-01-25
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Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
    3. The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan 030006, China
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