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Secondary metabolites from the dandelion-derived endophytic fungus Epicoccum sorghinum 1-2
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Bao-cong HAO1, Yao-yao ZHENG1, 2, Xu CHEN1, Qiu-xia CHEN1, Ruo-nan JI1, Min CHEN1, *
Acta Pharmaceutica Sinica | 2022, 57(7) : 2115 - 2119
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Acta Pharmaceutica Sinica | 2022, 57(7): 2115-2119
• Original Articles •
Secondary metabolites from the dandelion-derived endophytic fungus Epicoccum sorghinum 1-2
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Bao-cong HAO1, Yao-yao ZHENG1, 2, Xu CHEN1, Qiu-xia CHEN1, Ruo-nan JI1, Min CHEN1, *
Affiliations
  • 1. Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou 225127, China
  • 2. Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Published: 2022-07-12 doi: 10.16438/j.0513-4870.2021-1804
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The secondary metabolites from the dandelion-derived Epicoccum sorghinum 1-2 were isolated by silica gel and Sephadex gel column chromatography, and semi-preparative high performance liquid chromatography (HPLC). Their structures were identified by comprehensive NMR and MS methods. Their antibacterial activities were determined by filter paper method. Finally, seven compounds were isolated and identified from the fermentation product of E. sorghinum 1-2, including (4R*, 5R*, 6S*)-4, 5-dihydroxy-6-(6'-methylsalicyloxy)-2-methoxymethyl-2-cyclohexen-l-one (1), (4R*, 5R*, 6S*)-4, 5-dihydroxy-6-(6'-methylsalicyloxy)-2-methyl-2-cyclohexen-1-one (2), (4R, 5R, 6S)-4, 5-dihydroxy-6-(6'-methylsalicyloxy)-2-hydroxymethyl-2-cyclohexen-1-one (3), (-)-gabosine E (4), theobroxide (5), 3-chlorogentisyl alcohol (6), and 3-hydroxybenzyl alcohol (7), of which 1-5 are epoxydons, and 6 and 7 are phenolics. Compounds 1 and 2 are new structures reported for the first time. Compound 6 showed significant antibacterial activity against Staphylococcus aureus.

dandelion-derived endophytic fungus  /  Epicoccum sorghinum  /  secondary metabolite  /  epoxydon  /  antibacterial activity
Bao-cong HAO, Yao-yao ZHENG, Xu CHEN, Qiu-xia CHEN, Ruo-nan JI, Min CHEN. Secondary metabolites from the dandelion-derived endophytic fungus Epicoccum sorghinum 1-2[J]. Acta Pharmaceutica Sinica, 2022 , 57 (7) : 2115 -2119 . DOI: 10.16438/j.0513-4870.2021-1804
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Year 2022 volume 57 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2021-1804
  • Receive Date：2021-12-16
  • Online Date：2025-12-23
  • Published：2022-07-12
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History
  • Received：2021-12-16
  • Revised：2022-01-07
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Affiliations
    1. Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou 225127, China
    2. Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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