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The role of FGF21 in inhibition of heart failure with empagliflozin and related mechanisms
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Meng-xue ZHANG1, Yuan-yu WANG2, Ya-jun DUAN3, Shuang ZHANG1, *
Acta Pharmaceutica Sinica | 2022, 57(6) : 1664 - 1672
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Acta Pharmaceutica Sinica | 2022, 57(6): 1664-1672
• Special Reports: Oxidative Stress in Physiopathology and Pharmacological Treatment •
The role of FGF21 in inhibition of heart failure with empagliflozin and related mechanisms
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Meng-xue ZHANG1, Yuan-yu WANG2, Ya-jun DUAN3, Shuang ZHANG1, *
Affiliations
  • 1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China
  • 2. Beijing Institute of Biomedicine, Beijing 100091, China
  • 3. The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Hefei 230022, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2021-1753
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The aim of this study is to investigate the role of fibroblast growth factor 21 (FGF21) in empagliflozin (EMP) in treatment of heart failure and the related mechanisms. FGF21 knockout (FGF21 KO) and littermate wild-type (WT) mice induced by doxorubicin (Dox) were used to establish heart failure mouse model in vivo. The experiment process and animal welfare follow the regulations of Animal Ethics Committee of Hefei University of Technology strictly. The results suggest that Dox (5 mg·kg-1) induced typical heart failure symptoms in both WT and FGF21 KO mice. In WT mice, EMP (10 mg·kg-1) significantly improved Dox-induced cardiac atrophy, decreased myocardial systolic function, decreased left ventricular ejection fraction and shortened fraction; EMP treatment also significantly inhibited the increase of Dox-induced cardiotoxicity indexes (aspartate amino transferase, creatine kinase, hydroxybutyrate dehydrogenase, lactate dehydrogenase) in mice. Dox induced cardiac fibrosis, inflammation and oxidative stress were also significantly improved by EMP. However, in FGF21 KO mice, the therapeutic effects of EMP on heart failure was significantly inhibited. The results suggest that the function of EMP in treating heart failure partly depends on the presence of FGF21, and the mechanism may be related to the effect of FGF21 on improving fibrosis, inflammation and oxidative stress.

empagliflozin  /  fibroblast growth factor 21  /  heart failure  /  doxorubicin  /  fibrosis  /  inflammation  /  oxidative stress
Meng-xue ZHANG, Yuan-yu WANG, Ya-jun DUAN, Shuang ZHANG. The role of FGF21 in inhibition of heart failure with empagliflozin and related mechanisms[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1664 -1672 . DOI: 10.16438/j.0513-4870.2021-1753
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Year 2022 volume 57 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2021-1753
  • Receive Date：2021-12-06
  • Online Date：2025-12-23
  • Published：2022-06-12
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History
  • Received：2021-12-06
  • Revised：2022-04-27
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Affiliations
    1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China
    2. Beijing Institute of Biomedicine, Beijing 100091, China
    3. The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Hefei 230022, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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