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Research progress of natural silk fibroin's degradability and biocompatibility in vitro and in vivo
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Jia-ling CHENG, Jun YE, Hong-liang WANG, Yan-fang YANG, Zhi-yang CHEN, Hang ZHOU, Yu-ling LIU*
Acta Pharmaceutica Sinica | 2022, 57(4) : 1002 - 1009
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Acta Pharmaceutica Sinica | 2022, 57(4): 1002-1009
• Reviews •
Research progress of natural silk fibroin's degradability and biocompatibility in vitro and in vivo
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Jia-ling CHENG, Jun YE, Hong-liang WANG, Yan-fang YANG, Zhi-yang CHEN, Hang ZHOU, Yu-ling LIU*
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  • Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1658
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Silk fibroin is a kind of natural biodegradable polymer, which is stable, non-toxic, cheap and easy to obtain, and has no inflammatory reaction. Silk fibroin shows satisfactory degradability and biocompatibility, widely used as a promising material for biological tissue engineering and drug delivery carrier in the biomedical field. This review introduces the structure and constituent of silk fibroin, summarizes the research progress and methods of evaluating biodegradability and biocompatibility in vivo and in vitro, which provides reference for further research and application of silk fibroin.

silk fibroin  /  degradability  /  biocompatibility  /  biological tissue engineering  /  drug delivery system
Jia-ling CHENG, Jun YE, Hong-liang WANG, Yan-fang YANG, Zhi-yang CHEN, Hang ZHOU, Yu-ling LIU. Research progress of natural silk fibroin's degradability and biocompatibility in vitro and in vivo[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 1002 -1009 . DOI: 10.16438/j.0513-4870.2021-1658
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Article Info
doi: 10.16438/j.0513-4870.2021-1658
  • Receive Date：2021-11-19
  • Online Date：2025-12-22
  • Published：2022-04-12
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  • Received：2021-11-19
  • Revised：2021-12-20
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    Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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