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Research progress on the biosynthesis of natural sesterterpenoids
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De-sen LI2, 3, Yue-gui CHEN2, 3, Kai GUO1, Yi LING2, Yan LIU1, 2, *, Sheng-hong LI1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(4) : 931 - 942
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Acta Pharmaceutica Sinica | 2022, 57(4): 931-942
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Research progress on the biosynthesis of natural sesterterpenoids
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De-sen LI2, 3, Yue-gui CHEN2, 3, Kai GUO1, Yi LING2, Yan LIU1, 2, *, Sheng-hong LI1, 2, *
Affiliations
  • 1. State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
  • 3. University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1620
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Sesterterpenoids, composed of five isoprene units and biosynthetically derived from geranylfarnesyl diphosphate (GFDP), are a class of the precious terpenoids with approximately 1 300 natural products known to date. Natural sesterterpenoids are widely distributed and possess extreme structural complexity and diversity and remarkable biological activity. In recent decades, a series of important progresses have been made in sesterterpenoid biosynthesis with the development of genome mining and heterogeneous expression technologies. This paper mainly focuses on the advances in sesterterpenoid biosynthesis, including the biochemical functions and catalytic mechanisms of GFDP synthases, sesterterpene synthases and oxidases. This review would lay the foundation for in-depth investigation on the biosynthesis, biological activities and synthetic biology of sesterterpenoids.

natural product  /  sesterterpenoid  /  biosynthesis  /  geranylfarnesyl diphosphate synthase  /  sesterterpene synthase  /  oxidase
De-sen LI, Yue-gui CHEN, Kai GUO, Yi LING, Yan LIU, Sheng-hong LI. Research progress on the biosynthesis of natural sesterterpenoids[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 931 -942 . DOI: 10.16438/j.0513-4870.2021-1620
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Article Info
doi: 10.16438/j.0513-4870.2021-1620
  • Receive Date：2021-11-11
  • Online Date：2025-12-22
  • Published：2022-04-12
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History
  • Received：2021-11-11
  • Revised：2021-12-07
Funding
Affiliations
    1. State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
    3. University of Chinese Academy of Sciences, Beijing 100049, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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