收藏切换
Two new triterpenes from Maytenus guangxiensis with their antiproliferative activity
收藏切换
PDF
Yuan-yuan HUANG, Xue-gong JIA, Fu-sheng DENG, Jing-ya MO, Jing-quan YUAN*
Acta Pharmaceutica Sinica | 2022, 57(2) : 441 - 445
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(2): 441-445
Original Articles
Two new triterpenes from Maytenus guangxiensis with their antiproliferative activity
Full
Yuan-yuan HUANG, Xue-gong JIA, Fu-sheng DENG, Jing-ya MO, Jing-quan YUAN*
Affiliations
  • Scientific Experimental Center of Guangxi University of Chinese Medicine, Nanning 530200, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-1483
Outline
收藏切换

Four triterpenoids were isolated and purified from the 95% ethanol extract of Maytenus guangxiensis by silica gel column chromatography, Sephadex LH-20 column chromatography, MCI column chromatography and preparative RP-HPLC. Their structures were determined from their physicochemical properties and spectral data. They were identified as maytguanone A (1), maytguanone B (2), 11α-methoxyurs-12-ene-1β, 3β-diol (3), lup-20(29)-ene-3β, 11α-diol (4). Compounds 1 and 2 are new triterpenoids, along with compounds 3 and 4 were isolated from M. guangxiensis for the first time. The cytotoxicity of compounds 1, 3 and 4 was evaluated using the MTT procedure with three cancer cell lines. The results show that compound 3 displayed good inhibitory effects against HeLa, with an IC50 of 10.68 μmol·L-1.

Maytenus guangxiensis  /  triterpenoids  /  cytotoxic activity
Yuan-yuan HUANG, Xue-gong JIA, Fu-sheng DENG, Jing-ya MO, Jing-quan YUAN. Two new triterpenes from Maytenus guangxiensis with their antiproliferative activity[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 441 -445 . DOI: 10.16438/j.0513-4870.2021-1483
Year 2022 volume 57 Issue 2
PDF
154
60
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-1483
  • Receive Date:2021-10-14
  • Online Date:2025-12-22
  • Published:2022-02-12
Article Data
Affiliations
History
  • Received:2021-10-14
  • Revised:2021-11-11
Funding
Affiliations
    Scientific Experimental Center of Guangxi University of Chinese Medicine, Nanning 530200, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-1483
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT