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Research progress of tumor microenvironmentally regulating organelle targeted drug delivery system
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Shi-yang WU1, Shuang CHANG1, Qing CHEN2, Meng-hao SHI1, Ming ZHAO1, Hai-yang HU1, *, Da-wei CHEN1, *
Acta Pharmaceutica Sinica | 2022, 57(6) : 1771 - 1780
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Acta Pharmaceutica Sinica | 2022, 57(6): 1771-1780
• Reviews •
Research progress of tumor microenvironmentally regulating organelle targeted drug delivery system
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Shi-yang WU1, Shuang CHANG1, Qing CHEN2, Meng-hao SHI1, Ming ZHAO1, Hai-yang HU1, *, Da-wei CHEN1, *
Affiliations
  • 1. Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2. Department of Pharmacology, Iowa University, Iowa City 50011, USA
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2021-1353
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In recent years, the use of the body's immune system for anti-tumor immunotherapy has received extensive attention. However, the immunosuppressive tumor microenvironment (TME) limits the effect of immunotherapy. Therefore, overcoming the limitations of TME and immunosuppressive cells plays an important role in tumor immunotherapy. Nano agents have great potential to reprogram the immunosuppressive microenvironment and provide an effective strategy for immunotherapy. With the continuous development of active targeting nano carrier technology and the deepening of the research on drug action sites, subcellular organ targeting nano carrier materials with more accurate active targeting function have also attracted more and more attention. This review will briefly introduce the relationship between subcellular organelles and tumor, summarize the design strategy and research progress of targeted nano drug delivery system based on the characteristics of acidity, reactive oxygen species (ROS) activity, immunogenicity, and TME of immunosuppressive cells, to provide reference for the construction of subcellular pathway targeted drug delivery system in tumor immunotherapy.

drug delivery system  /  tumor microenvironment  /  organelle  /  targeting  /  hydrogen-ion concentration  /  reactive oxygen species  /  immunogenicity  /  immunosuppression
Shi-yang WU, Shuang CHANG, Qing CHEN, Meng-hao SHI, Ming ZHAO, Hai-yang HU, Da-wei CHEN. Research progress of tumor microenvironmentally regulating organelle targeted drug delivery system[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1771 -1780 . DOI: 10.16438/j.0513-4870.2021-1353
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Article Info
doi: 10.16438/j.0513-4870.2021-1353
  • Receive Date：2021-09-16
  • Online Date：2025-12-23
  • Published：2022-06-12
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History
  • Received：2021-09-16
  • Revised：2021-11-17
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Affiliations
    1. Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
    2. Department of Pharmacology, Iowa University, Iowa City 50011, USA
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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