Home Journals Articles Updates About
CN
image
收藏切换
Research progress of Nrf2 inhibitor in tumor therapy
收藏切换
PDF
Yi MOU1, Yu SONG1, Shuai WEN1, Yan WANG1, Zheng-yu JIANG2, *
Acta Pharmaceutica Sinica | 2022, 57(2) : 321 - 330
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(2): 321-330
• Reviews •
Research progress of Nrf2 inhibitor in tumor therapy
Full
Yi MOU1, Yu SONG1, Shuai WEN1, Yan WANG1, Zheng-yu JIANG2, *
Affiliations
  • 1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China
  • 2. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-1346
Outline
收藏切换

Nrf2 is a multi-effect transcription factor, which plays a crucial role in cytoprotective system. With the deepening of research on new regulatory modes and biologic functions of Nrf2, the oncogenic role of Nrf2 in malignant transformed tumors is increasingly obvious. More and more evidences show that Nrf2 is involved in the whole process of tumor occurrence, development, metastasis and prognosis, and inhibiting Nrf2 may be a promising strategy in tumor therapy. However, the development of Nrf2 inhibitors is still in early stage. In this paper, the biological function of Nrf2 and its dual role in tumor are briefly introduced, and representative Nrf2 inhibitors are reviewed according to their structure types, so as to provide reference and ideas for the development of anti-tumor drugs centering on the regulation of Nrf2.

Nrf2  /  tumor  /  chemotherapy for cancer  /  inhibitors
Yi MOU, Yu SONG, Shuai WEN, Yan WANG, Zheng-yu JIANG. Research progress of Nrf2 inhibitor in tumor therapy[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 321 -330 . DOI: 10.16438/j.0513-4870.2021-1346
Appendix
Less
Year 2022 volume 57 Issue 2
PDF
280
147
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-1346
  • Receive Date：2021-09-15
  • Online Date：2025-12-22
  • Published：2022-02-12
Article Data
Affiliations
History
  • Received：2021-09-15
  • Revised：2021-11-09
Funding
Affiliations
    1. College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China
    2. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-1346
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House