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Research progress on anti-tubercular drugs
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Zi-hao ZHU1, Wen-xuan ZHANG1, Tian-lei LI1, 2, *, Song WU1, *
Acta Pharmaceutica Sinica | 2022, 57(4) : 892 - 902
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Acta Pharmaceutica Sinica | 2022, 57(4): 892-902
• Reviews •
Research progress on anti-tubercular drugs
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Zi-hao ZHU1, Wen-xuan ZHANG1, Tian-lei LI1, 2, *, Song WU1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medicinal University, Guiyang 550025, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1266
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Tuberculosis (TB) is an enduring threat to global health. The epidemic persists with growing drug resistance, especially for extensively drug-resistant TB. Therefore, the treatment for TB and its associated multidrug resistance has been an ongoing challenge. Due to the greater attention and investment in the elimination of this disease, significant progress has been achieved. Bedaquiline, delamanid, and pretomanid have been approved for the clinical use. In addition, two dozens new anti-TB drugs are currently in clinical testing. China has contributed four new drugs TBI-223, TBI-166, aulimanid, and WX-081. The aim of this review is to summarize the recent advances in anti-TB drug development. Based on the different clinical stages of these anti-TB drugs, we mainly focus on mechanism of action, in vitro and in vivo pharmacological studies, pharmacokinetics and clinical studies.

antituberculosis drug  /  new chemical entity  /  new drug research  /  clinical stage  /  drug-resistant tuberculosis
Zi-hao ZHU, Wen-xuan ZHANG, Tian-lei LI, Song WU. Research progress on anti-tubercular drugs[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 892 -902 . DOI: 10.16438/j.0513-4870.2021-1266
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Article Info
doi: 10.16438/j.0513-4870.2021-1266
  • Receive Date：2021-08-31
  • Online Date：2025-12-22
  • Published：2022-04-12
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History
  • Received：2021-08-31
  • Revised：2021-09-26
Funding
Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medicinal University, Guiyang 550025, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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