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Progress and prospect in the clinical translation of cancer nanomedicine
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Zhao-hui WANG, Yu-ling LIU*
Acta Pharmaceutica Sinica | 2022, 57(1) : 134 - 141
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Acta Pharmaceutica Sinica | 2022, 57(1): 134-141
• Reviews •
Progress and prospect in the clinical translation of cancer nanomedicine
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Zhao-hui WANG, Yu-ling LIU*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2022-01-12 doi: 10.16438/j.0513-4870.2021-1259
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Nanotechnology has shown broad application prospects in the diagnosis and treatment of cancer. Currently, nearly 80 cancer nanomedicines are under clinical investigation, and many have been approved with enhanced anti-tumor efficacy and decreased side effects. However, the presence of various barriers in related basic research, process control and clinical trials lead to extremely low translation rate. From the perspective of clinical commercialization, we summarized the progress, clinical status, challenges and opportunities of cancer nanomedicine, and presented a cutting-edge prospect on the rational design of nanomedicine and clinical trial strategies.

tumor therapy  /  nanomedicine  /  targeted therapy  /  clinical translation  /  patient stratification  /  biomarker
Zhao-hui WANG, Yu-ling LIU. Progress and prospect in the clinical translation of cancer nanomedicine[J]. Acta Pharmaceutica Sinica, 2022 , 57 (1) : 134 -141 . DOI: 10.16438/j.0513-4870.2021-1259
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Article Info
doi: 10.16438/j.0513-4870.2021-1259
  • Receive Date：2021-08-30
  • Online Date：2025-12-22
  • Published：2022-01-12
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  • Received：2021-08-30
  • Revised：2021-09-28
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Affiliations
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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