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Research progress on the mechanism of bone marrow mesenchymal stem cells in improving liver fibrosis
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Yi DING, Xiao-min LUO, Bin YANG, Bo-yu ZHANG, Jian GU*, Zhi-xiang YUAN*
Acta Pharmaceutica Sinica | 2022, 57(4) : 863 - 874
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Acta Pharmaceutica Sinica | 2022, 57(4): 863-874
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Research progress on the mechanism of bone marrow mesenchymal stem cells in improving liver fibrosis
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Yi DING, Xiao-min LUO, Bin YANG, Bo-yu ZHANG, Jian GU*, Zhi-xiang YUAN*
Affiliations
  • College of Pharmacy, Southwest Minzu University, Chengdu 610041, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1220
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Liver fibrosis is characterized by scarring of liver tissue, which is an intermediate pathological process of chronic liver disease developing into liver cancer. Its mechanism involves multiple signal pathways, and its reversibility is a current research hotspot. Bone marrow mesenchymal stem cells (BMSCs) are adult stem cells with multi-differentiation potential. They have ability to differentiate into liver-like cells in vivo and in vitro to perform normal liver cell functions. Modern pharmacological experimental studies have shown that the use of BMSCs alone or in combination with active factors, Chinese medicine or Chinese medicine monomers, genetic modification and other methods can promote their proliferation, differentiation, and migration, improve the therapeutic effect, and play a role in improving liver fibrosis. By summarizing the existing literature, the therapeutic mechanism of BMSCs in improving liver fibrosis is reviewed from the aspects of the pathogenesis of liver fibrosis, the improvement mechanism of liver fibrosis, the biological characteristics of BMSCs and its improvement mechanism, so as to provide reference for the later development of BMSCs cell therapy.

liver fibrosis  /  improvement mechanism  /  bone marrow mesenchymal stem cell  /  combination therapy  /  mechanism study  /  application prospect
Yi DING, Xiao-min LUO, Bin YANG, Bo-yu ZHANG, Jian GU, Zhi-xiang YUAN. Research progress on the mechanism of bone marrow mesenchymal stem cells in improving liver fibrosis[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 863 -874 . DOI: 10.16438/j.0513-4870.2021-1220
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doi: 10.16438/j.0513-4870.2021-1220
  • Receive Date：2021-08-23
  • Online Date：2025-12-22
  • Published：2022-04-12
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  • Received：2021-08-23
  • Revised：2021-09-28
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    College of Pharmacy, Southwest Minzu University, Chengdu 610041, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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