Home Journals Articles Updates About
CN
image
收藏切换
Applications of nanobodies in G protein-coupled receptors research
收藏切换
PDF
Yi WANG, Yan-Jie ZHAO, Shuai LI*
Acta Pharmaceutica Sinica | 2022, 57(4) : 990 - 1001
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(4): 990-1001
• Reviews •
Applications of nanobodies in G protein-coupled receptors research
Full
Yi WANG, Yan-Jie ZHAO, Shuai LI*
Affiliations
  • Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1203
Outline
收藏切换

G protein-coupled receptors (GPCRs), the largest family of transmembrane receptors in the human, contain seven transmembrane helices, and are usually regarded as critical drug targets because of their key roles in multiple diseases. Currently, 30%-40% approved drugs target GPCRs. Nanobodies (also known as single domain antibodies) are important research tools for GPCRs due to their small molecular weight, good biochemical properties and high affinity for "cracks or cavities". In addition, nanobodies have long complementarity determining region 3 (CDR3) loops which can be inserted deeply into GPCRs ligand binding pockets, efficiently binding to the folds. This review summarizes the characteristics of nanobodies and their applications in GPCRs research and briefly introduces the current identification routes of targeted GPCRs nanobodies, which could provide new idea and method for applications of nanobodies in GPCRs research.

G protein coupled receptor  /  single-domain antibody  /  nanobody  /  crystallization  /  chemotaxis
Yi WANG, Yan-Jie ZHAO, Shuai LI. Applications of nanobodies in G protein-coupled receptors research[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 990 -1001 . DOI: 10.16438/j.0513-4870.2021-1203
Appendix
Less
Year 2022 volume 57 Issue 4
PDF
173
58
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-1203
  • Receive Date：2021-08-19
  • Online Date：2025-12-22
  • Published：2022-04-12
Article Data
Affiliations
History
  • Received：2021-08-19
  • Revised：2021-09-29
Funding
Affiliations
    Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-1203
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House