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Progress in the prevention and treatment of age-related macular degeneration with active ingredients of traditional Chinese medicine
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Cong-yan LIU1, 2, Ding QU1, 2, *, Yan CHEN1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(5) : 1219 - 1234
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Acta Pharmaceutica Sinica | 2022, 57(5): 1219-1234
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Progress in the prevention and treatment of age-related macular degeneration with active ingredients of traditional Chinese medicine
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Cong-yan LIU1, 2, Ding QU1, 2, *, Yan CHEN1, 2, *
Affiliations
  • 1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
  • 2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
Published: 2022-05-12 doi: 10.16438/j.0513-4870.2021-1157
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Age-related macular degeneration (AMD) is one of the main causes of vision loss among middle-aged and elderly people worldwide. The prevention and treatment of AMD is a current topic of interest in ophthalmology but remains challenging. Oxidative stress-induced retinal pigment epithelial cell autophagic dysfunction, cellular senescence, and an abnormal immune inflammatory response are key pathogenic factors for AMD. Many bioactive ingredients of traditional Chinese medicine not only exert anti-oxidative, anti-inflammatory, anti-aging, and anti-apoptotic effects, but also prevent/block the occurrence of AMD through different pathways. This review summarizes our current understanding of the pathogenesis of AMD, the types of natural bioactive ingredients capable of treating AMD, as well as the known mechanisms by which these agents act, and may provide new strategies for the prevention and treatment of AMD.

natural bioactive ingredient  /  age-related macular degeneration  /  retinal pigment epithelial cell  /  oxidative stress  /  autophagy  /  inflammation
Cong-yan LIU, Ding QU, Yan CHEN. Progress in the prevention and treatment of age-related macular degeneration with active ingredients of traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2022 , 57 (5) : 1219 -1234 . DOI: 10.16438/j.0513-4870.2021-1157
Year 2022 volume 57 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2021-1157
  • Receive Date:2021-08-08
  • Online Date:2025-12-23
  • Published:2022-05-12
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  • Received:2021-08-08
  • Revised:2021-09-26
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Affiliations
    1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
    2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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