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Influence of nebulizers and add-on spacers on nebulization performances of Re-Du-Ning injection
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Chao-yi LI1, Fei-fei YANG1, Chun-yu LIU1, Yong-hong LIAO1, 2, 3, *
Acta Pharmaceutica Sinica | 2021, 56(10) : 2676 - 2681
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Acta Pharmaceutica Sinica | 2021, 56(10): 2676-2681
• Special Reports: Inhalation Drug Delivery System •
Influence of nebulizers and add-on spacers on nebulization performances of Re-Du-Ning injection
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Chao-yi LI1, Fei-fei YANG1, Chun-yu LIU1, Yong-hong LIAO1, 2, 3, *
Affiliations
  • 1. Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
  • 2. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
  • 3. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China
Published: 2021-10-12 doi: 10.16438/j.0513-4870.2021-1120
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The objective of the study was to investigate the effects of nebulizers and add-on spacers on nebulization performances of Re-Du-Ning injection. Chlorogenic acid and geniposide were taken as the chemical markers of the injection. In vitro nebulization performances including real-time particle size distribution, aerodynamic particle size distribution (APSD), respirable drug delivery rate (RDDR) and percentage of respirable delivered dose (RDD%), residual rate and nebulization time were determined after nebulization of Re-Du-Ning injection via jet or mesh nebulizers. The delivery efficiency was the ratio of delivery dose to the drug content of the injection. The aerosol delivery efficiency of Re-Du-Ning injection for the jet nebulizer was about 30% of the nominal dose whereas those for mesh nebulizers varied from 24% to 35% in adult breathing pattern. Upon the inclusion of spacers, the delivery efficiencies of mesh nebulizers increased to 37%-68% whereas the presence of a spacer decreased the delivery efficiency of the jet nebulizer. When the aerosols of mesh nebulizer exhibited comparative fine particle fraction (FPF) and mass median aerodynamic diameter (MMAD) to those of the jet nebulizer, the RDD% of the former nebulizer with a spacer was more than two folds of the latter. These results indicated that the addition of spacer was demonstrated to significantly improve the delivery efficiency of Re-Du-Ning injection by mesh nebulizers.

Re-Du-Ning injection  /  nebulizer  /  inhalation spacer  /  aerodynamic particle size distribution  /  delivery efficiency
Chao-yi LI, Fei-fei YANG, Chun-yu LIU, Yong-hong LIAO. Influence of nebulizers and add-on spacers on nebulization performances of Re-Du-Ning injection[J]. Acta Pharmaceutica Sinica, 2021 , 56 (10) : 2676 -2681 . DOI: 10.16438/j.0513-4870.2021-1120
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Article Info
doi: 10.16438/j.0513-4870.2021-1120
  • Receive Date：2021-07-28
  • Online Date：2025-12-18
  • Published：2021-10-12
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History
  • Received：2021-07-28
  • Revised：2021-08-25
Funding
Affiliations
    1. Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    2. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
    3. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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