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Research progress of polysaccharides-based targeted oral drug delivery systems for colonic diseases treatment
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Long HUANG1, 2, Wen ZENG2, 3, Bing XU1, 4, Can-yang ZHANG1, Shao-hua MA1, Chong ZHANG2, 3, 5, Yi WANG2, 3, *, Xin-hui XING1, 2, 3, 4, 5, *
Acta Pharmaceutica Sinica | 2022, 57(4) : 976 - 989
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Acta Pharmaceutica Sinica | 2022, 57(4): 976-989
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Research progress of polysaccharides-based targeted oral drug delivery systems for colonic diseases treatment
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Long HUANG1, 2, Wen ZENG2, 3, Bing XU1, 4, Can-yang ZHANG1, Shao-hua MA1, Chong ZHANG2, 3, 5, Yi WANG2, 3, *, Xin-hui XING1, 2, 3, 4, 5, *
Affiliations
  • 1. Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
  • 2. Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
  • 3. MOE Key Laboratory for Industrial Biocatalysis, Beijing 100084, China
  • 4. Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518055, China
  • 5. Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1073
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Polysaccharides as one of the most common drug delivery materials have the excellent advantages, such as diverse natural sources, high biocompatibility and multi-functions. Polysaccharides have been investigated and widely used in food industry, pharmaceutical and medical fields especially in the targeted oral drug delivery for colonic diseases treatment with important research values and great potential applications. Inspired by the unique properties of polysaccharides, researchers around the world have developed the cross-linked nanoparticles, self-assembled nanoparticles and hydrogels, focusing on various drug delivery strategies such as pH-sensitive, microbial enzyme-responsive, reactive oxygen species-responsive, mucoadhesive and receptor-targeted. Exhilaratingly, the polysaccharides-based therapeutics have shown high efficacy for the treatment of digestive tract diseases, such as colitis or colonic cancer. Herein, we summarized the research progress of polysaccharides-based targeted oral drug delivery systems for colonic diseases treatment, and discussed the perspectives of the researches and application development in future.

polysaccharide  /  oral administration  /  pharmaceutic preparation  /  drug delivery system  /  colonic disease
Long HUANG, Wen ZENG, Bing XU, Can-yang ZHANG, Shao-hua MA, Chong ZHANG, Yi WANG, Xin-hui XING. Research progress of polysaccharides-based targeted oral drug delivery systems for colonic diseases treatment[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 976 -989 . DOI: 10.16438/j.0513-4870.2021-1073
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Article Info
doi: 10.16438/j.0513-4870.2021-1073
  • Receive Date：2021-07-20
  • Online Date：2025-12-22
  • Published：2022-04-12
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History
  • Received：2021-07-20
  • Revised：2021-10-28
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Affiliations
    1. Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
    2. Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
    3. MOE Key Laboratory for Industrial Biocatalysis, Beijing 100084, China
    4. Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518055, China
    5. Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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