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The multiple roles of AMPK in fibrotic diseases
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Xuan GU, Ming-han CHENG, Jian GAO*
Acta Pharmaceutica Sinica | 2021, 56(11) : 2923 - 2933
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Acta Pharmaceutica Sinica | 2021, 56(11): 2923-2933
• Special Reports: Recent Advances in Visceral Organ Fibrosis and Antifibrotic Drug Discovery •
The multiple roles of AMPK in fibrotic diseases
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Xuan GU, Ming-han CHENG, Jian GAO*
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  • Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200120, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0960
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Fibrosis is a common manifestation of organ damage and failure. According to relevant statistics in the United States, deaths caused by fibrotic diseases account for 45% of all deaths in the country. Therefore, fibrotic diseases have received widespread attention worldwide. As a key kinase that regulates energy balance, AMP-activated protein kinase (AMPK), which mainly controls the transformation of cells from anabolic to catabolism, and restores the energy balance by phosphorylating its substrates. Therefore, it has become the core of treatment for diabetes and other metabolic-related diseases. Numerous recent pathological studies have shown that the expression of AMPK in fibrotic tissues is significantly down-regulated compared with normal tissues, and activation of AMPK could improve various fibrotic pathological processes (including autophagy dysfunction, oxidative stress, fibroblast proliferation, epithelial-mesenchymal transition, fibroblast-to-myofibroblast differentiation). Therefore, this review will discuss the structure and function of AMPK and its role in important phenotypes of fibrotic diseases, and provide evidence for AMPK as an important target for prevention and treatment of fibrosis.

AMPK  /  fibrosis  /  autophagy  /  oxidative stress  /  fibroblast proliferation  /  epithelial-mesenchymal transition  /  fibroblast-to-myofibroblast differentiation
Xuan GU, Ming-han CHENG, Jian GAO. The multiple roles of AMPK in fibrotic diseases[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 2923 -2933 . DOI: 10.16438/j.0513-4870.2021-0960
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doi: 10.16438/j.0513-4870.2021-0960
  • Receive Date：2021-06-28
  • Online Date：2025-12-18
  • Published：2021-11-12
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  • Received：2021-06-28
  • Revised：2021-07-18
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    Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200120, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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