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Research progress on the mechanism of ferroptosis in regulating liver fibrosis
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Hao CHEN1, 2, Xiao-feng LI3, 4, Hua WANG5, *
Acta Pharmaceutica Sinica | 2021, 56(11) : 2916 - 2922
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Acta Pharmaceutica Sinica | 2021, 56(11): 2916-2922
Special Reports: Recent Advances in Visceral Organ Fibrosis and Antifibrotic Drug Discovery
Research progress on the mechanism of ferroptosis in regulating liver fibrosis
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Hao CHEN1, 2, Xiao-feng LI3, 4, Hua WANG5, *
Affiliations
  • 1. Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • 2. The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei 230022, China
  • 3. School of Pharmacy, Anhui Medical University, Hefei 230032, China
  • 4. Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China
  • 5. Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0959
Outline
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Liver fibrosis is a common pathological process that many chronic liver diseases must undergo to develop into cirrhosis and hepatocellular carcinoma. Liver fibrosis is regulated by a variety of cytokines and signal pathways during its occurrence and development. In recent years, a large number of studies showed that ferroptosis is closely related to liver fibrosis. Compared with normal liver, the levels of irons and lipid peroxidation in the liver with fibrosis are significantly increased. Therefore, ferroptosis may be a potential target for the diagnosis, prevention, and treatment of liver fibrosis. This review summarizes the role of ferroptosis in liver fibrosis, thus to provide new ideas for the treatment of liver fibrosis.

ferroptosis  /  hepatic stellate cell  /  liver fibrosis  /  iron  /  lipid peroxidation
Hao CHEN, Xiao-feng LI, Hua WANG. Research progress on the mechanism of ferroptosis in regulating liver fibrosis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 2916 -2922 . DOI: 10.16438/j.0513-4870.2021-0959
Year 2021 volume 56 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2021-0959
  • Receive Date:2021-06-28
  • Online Date:2025-12-18
  • Published:2021-11-12
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History
  • Received:2021-06-28
  • Revised:2021-07-30
Funding
Affiliations
    1. Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
    2. The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei 230022, China
    3. School of Pharmacy, Anhui Medical University, Hefei 230032, China
    4. Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, China
    5. Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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