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Comparative analysis of chemical constituents in hawthorn leaves from different sources
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Wei ZHENG1, Ming ZHOU1, 2, Shuang-yan WANG1, Qi LI1, Jie ZHANG1, Ye ZHAO3, Xiao-hui ZHENG3, Bao-lin GUO2, Bai-ping MA1, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3526 - 3539
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Acta Pharmaceutica Sinica | 2021, 56(12): 3526-3539
• Original Articles •
Comparative analysis of chemical constituents in hawthorn leaves from different sources
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Wei ZHENG1, Ming ZHOU1, 2, Shuang-yan WANG1, Qi LI1, Jie ZHANG1, Ye ZHAO3, Xiao-hui ZHENG3, Bao-lin GUO2, Bai-ping MA1, *
Affiliations
  • 1. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
  • 2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
  • 3. College of Life Sciences, Northwest University, Xi'an 710069, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-0884
Outline
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We identified and analyzed the components and chemical constituents of hawthorn leaves of Crataegus pinnatifida Bge. (wild) and C. pinnatifida Bge. var major N. E. Br (cultivated) by using ultra high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MSE) combined with UNIFI data analysis platform and multivariate statistics. Fifty-eight chemical compounds were identified, including organic acids, flavonoids, triterpenoic acids, monoterpenes and sesquiterpenoids; among them, terpenoid content was the most abundant. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to identify the differential components of hawthorn leaves from two sources. The results show that there are differences in the chemical compositions of the two sources, including 24 flavonoids and terpenoids (including monoterpenoids, sesquiterpenoids and triterpenoid acids). The types of flavonoids (such as rutin, vitexin-2''-O-rhamnoside, isovitexin-2''-O-rhamnoside, hyperoside, quercetin-3-O-β-D-glucoside) and terpenoids (crataegolic acid, corosolic acid and ursolic acid) in C. pinnatifida were more varied than those found in C. pinnatifida Bge. var major N. E. Br, and their contents were relatively higher. This study provides a comprehensively analysis of the different chemical components of hawthorn leaves from two sources listed in the Chinese Pharmacopoeia, and provides a basis for the selection of raw materials and the potential development and utilization of hawthorn leaves.

hawthorn leaf  /  different sources  /  UHPLC-Q-TOF/MSE  /  identification of chemical constituents  /  differential analysis
Wei ZHENG, Ming ZHOU, Shuang-yan WANG, Qi LI, Jie ZHANG, Ye ZHAO, Xiao-hui ZHENG, Bao-lin GUO, Bai-ping MA. Comparative analysis of chemical constituents in hawthorn leaves from different sources[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3526 -3539 . DOI: 10.16438/j.0513-4870.2021-0884
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Article Info
doi: 10.16438/j.0513-4870.2021-0884
  • Receive Date：2021-06-16
  • Online Date：2025-12-18
  • Published：2021-12-12
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History
  • Received：2021-06-16
  • Revised：2021-08-10
Funding
Affiliations
    1. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
    2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    3. College of Life Sciences, Northwest University, Xi'an 710069, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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