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Research progress of PDI in amyotrophic lateral sclerosis
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Yong-xue ZHANG1, 2, Ze-yao PU1, Ya-ting AN1, Wei ZHANG1, Yi-ying WANG1, Han HAO1, Hui-ran ZHANG1, Hai-lin ZHANG1, Xiao-na DU1, *
Acta Pharmaceutica Sinica | 2021, 56(10) : 2735 - 2741
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Acta Pharmaceutica Sinica | 2021, 56(10): 2735-2741
• Reviews •
Research progress of PDI in amyotrophic lateral sclerosis
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Yong-xue ZHANG1, 2, Ze-yao PU1, Ya-ting AN1, Wei ZHANG1, Yi-ying WANG1, Han HAO1, Hui-ran ZHANG1, Hai-lin ZHANG1, Xiao-na DU1, *
Affiliations
  • 1. Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China
  • 2. Department of Pharmacy, Handan First Hospital, Handan 056002, China
Published: 2021-10-12 doi: 10.16438/j.0513-4870.2021-0686
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Protein disulfide isomerase (PDI), also named PDIA1, is an archetype member of protein disulfide isomerase family, which mainly exists in endoplasmic reticulum and plays an important role in pathophysiological progress via enzyme activity and molecular chaperone function helping protein folding correctly. Amyotrophic lateral sclerosis (ALS) is a kind of neurodegenerative diseases characterized by abnormal protein aggregation. Recently, PDI mutants have been found in ALS patients and the important role of PDI protein in the development of ALS has also been confirmed. Here, we focus on the recent studies of PDI in ALS hoping to provide a novel target for the treatment of ALS.

protein disulfide isomerase  /  chaperone  /  amyotrophic lateral sclerosis  /  neurodegenerative disease
Yong-xue ZHANG, Ze-yao PU, Ya-ting AN, Wei ZHANG, Yi-ying WANG, Han HAO, Hui-ran ZHANG, Hai-lin ZHANG, Xiao-na DU. Research progress of PDI in amyotrophic lateral sclerosis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (10) : 2735 -2741 . DOI: 10.16438/j.0513-4870.2021-0686
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Article Info
doi: 10.16438/j.0513-4870.2021-0686
  • Receive Date：2021-05-08
  • Online Date：2025-12-18
  • Published：2021-10-12
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History
  • Received：2021-05-08
  • Revised：2021-06-17
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Affiliations
    1. Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China
    2. Department of Pharmacy, Handan First Hospital, Handan 056002, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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