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Recent advances of HIF-2α in pulmonary hypertension
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Lei JI1, 2, 3, Zhan-qiang LI1, 2, *, Dian-xiang LU1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(2) : 277 - 286
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Acta Pharmaceutica Sinica | 2022, 57(2): 277-286
• Reviews •
Recent advances of HIF-2α in pulmonary hypertension
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Lei JI1, 2, 3, Zhan-qiang LI1, 2, *, Dian-xiang LU1, 2, *
Affiliations
  • 1. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
  • 2. Key Laboratory of High Altitude Medicine(Ministry of Education), Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province(Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Xining 810001, China
  • 3. Qinghai Provincial People's Hospital, Xining 810007, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-0632
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Pulmonary hypertension (PH) is a kind of disease characterized by progressive increase of pulmonary vascular resistance and occlusive vascular remodeling. Hypoxic inductive factor-2α (HIF-2α) plays an important role in the abnormal proliferation of pulmonary vascular cells and pulmonary vascular remodeling. This review focuses on the role of HIF-2α in pulmonary hypertension at the cellular and the global level, and candidates targeting HIF-2α for the treatment of pulmonary hypertension, in order to better understand the pathogenesis of PH and find effective treatments.

hypoxic inducible factor-2α  /  pulmonary hypertension  /  endothelial cell  /  hypoxic inducible factor-1α  /  treatment
Lei JI, Zhan-qiang LI, Dian-xiang LU. Recent advances of HIF-2α in pulmonary hypertension[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 277 -286 . DOI: 10.16438/j.0513-4870.2021-0632
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Article Info
doi: 10.16438/j.0513-4870.2021-0632
  • Receive Date：2021-04-26
  • Online Date：2025-12-22
  • Published：2022-02-12
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History
  • Received：2021-04-26
  • Revised：2021-05-30
Funding
Affiliations
    1. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
    2. Key Laboratory of High Altitude Medicine(Ministry of Education), Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province(Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Xining 810001, China
    3. Qinghai Provincial People's Hospital, Xining 810007, China
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