Home Journals Articles Updates About
CN
image
收藏切换
Glycosylation analysis of therapeutic proteins
收藏切换
PDF
Hong WANG1, Hong-rui YIN1, Yi-le CHEN2, Xin-xin FANG1, Ming-ming XU1, Cheng TIAN2, Jin XU3, Gang CHEN1, Hong SHAO1, *
Acta Pharmaceutica Sinica | 2021, 56(10) : 2779 - 2786
Less
收藏切换
Acta Pharmaceutica Sinica | 2021, 56(10): 2779-2786
• Reviews •
Glycosylation analysis of therapeutic proteins
Full
Hong WANG1, Hong-rui YIN1, Yi-le CHEN2, Xin-xin FANG1, Ming-ming XU1, Cheng TIAN2, Jin XU3, Gang CHEN1, Hong SHAO1, *
Affiliations
  • 1. Shanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai 201203, China
  • 2. Analytical Sciences, WuXi Biologics (Shanghai) Co., Ltd., Shanghai 200131, China
  • 3. State Key Laboratory of Antibody Medicine and Targeted Therapy, NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Zhangjiang Biotechnology Co., Ltd., Shanghai 201203, China
Published: 2021-10-12 doi: 10.16438/j.0513-4870.2021-0579
Outline
收藏切换

As one of the most critical post-translational modifications, glycosylation of therapeutic proteins has a profound impact on their safety, efficacy and consistent. However, glycosylation is not a template-driven process, therefore variability in the glycosylation pattern of a protein can arise. This makes challenges of glycan analysis and control. Here, we review the overall control strategy, basic requirements for standardized protocols and the novel technologies of glycosylation analysis to accelerate the development of therapeutic glycoproteins.

therapeutic glycoprotein  /  glycosylation analysis  /  overall control strategy
Hong WANG, Hong-rui YIN, Yi-le CHEN, Xin-xin FANG, Ming-ming XU, Cheng TIAN, Jin XU, Gang CHEN, Hong SHAO. Glycosylation analysis of therapeutic proteins[J]. Acta Pharmaceutica Sinica, 2021 , 56 (10) : 2779 -2786 . DOI: 10.16438/j.0513-4870.2021-0579
Appendix
Less
Year 2021 volume 56 Issue 10
PDF
139
54
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-0579
  • Receive Date：2021-04-17
  • Online Date：2025-12-18
  • Published：2021-10-12
Article Data
Affiliations
History
  • Received：2021-04-17
  • Revised：2021-07-15
Funding
Affiliations
    1. Shanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai 201203, China
    2. Analytical Sciences, WuXi Biologics (Shanghai) Co., Ltd., Shanghai 200131, China
    3. State Key Laboratory of Antibody Medicine and Targeted Therapy, NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Zhangjiang Biotechnology Co., Ltd., Shanghai 201203, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-0579
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House