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Multivariate statistical analysis based on GC-MS metabolomics and antibacterial activity of Aster yunnanensis and Pulicaria insignis
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Li LI, Ying-xiu ZHANG, Ri-za ZHAO, Wen-fu CAI, Zhi-feng ZHANG*
Acta Pharmaceutica Sinica | 2021, 56(11) : 3118 - 3129
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Acta Pharmaceutica Sinica | 2021, 56(11): 3118-3129
• Original Articles •
Multivariate statistical analysis based on GC-MS metabolomics and antibacterial activity of Aster yunnanensis and Pulicaria insignis
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Li LI, Ying-xiu ZHANG, Ri-za ZHAO, Wen-fu CAI, Zhi-feng ZHANG*
Affiliations
  • College of Pharmacy, Institute of Tibetan Plateau, Southwest Minzu University, Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission, Chengdu 610041, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0568
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The study was undertaken to clarify the differences in metabolite groups between Aster yunnanensis and Pulicaria insignis to establish plant origin and identify plant resources. Non-target metabolomics of A. yunnanensis and P. insignis was undertaken with sample derivatives and gas chromatography-mass spectrometry (GC-MS). Principal component analysis (PCA), partial least-squares discriminant analysis (PLS-DA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) were used to characterize the differing metabolites of A. yunnanensis and P. insignis. Correlation analysis of these metabolites and metabolic pathway analysis allowed us to identify metabolic pathway changes between samples. Characterization of the antibacterial activity of the essential oil from A. yunnanensis and P. insignis showed that 384 metabolites were identified in the two species, including amino acids and peptides, phenylpropanoids, aromatics, glycoside, nucleotide, flavonoid, alkaloids, saccharides, vitamin, organic acid, lipids, esters, alcohol. A total of 92 differential metabolites with significant differences in content (P < 0.05, VIP > 1) were identified. In conclusion, a new method based on pre-column derivatives and GC-MS metabolomics was used to distinguish and compare A. yunnanensis and P. insignis metabolites.

Aster yunnanensis  /  Pulicaria insignis  /  GC-MS  /  metabolomics  /  antibacterial activity
Li LI, Ying-xiu ZHANG, Ri-za ZHAO, Wen-fu CAI, Zhi-feng ZHANG. Multivariate statistical analysis based on GC-MS metabolomics and antibacterial activity of Aster yunnanensis and Pulicaria insignis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 3118 -3129 . DOI: 10.16438/j.0513-4870.2021-0568
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Article Info
doi: 10.16438/j.0513-4870.2021-0568
  • Receive Date：2021-04-21
  • Online Date：2025-12-18
  • Published：2021-11-12
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  • Received：2021-04-21
  • Revised：2021-08-30
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    College of Pharmacy, Institute of Tibetan Plateau, Southwest Minzu University, Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission, Chengdu 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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