Home Journals Articles Updates About
CN
image
收藏切换
Progress in the pleiotropic activity of metformin
收藏切换
Wen-xuan XIAO1, Ya-dan LUO1, Jian-guo CHEN1, 2, Fang WANG1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3385 - 3391
Less
收藏切换
Acta Pharmaceutica Sinica | 2021, 56(12): 3385-3391
• Reviews •
Progress in the pleiotropic activity of metformin
Full
Wen-xuan XIAO1, Ya-dan LUO1, Jian-guo CHEN1, 2, Fang WANG1, 2, *
Affiliations
  • 1. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • 2. Hubei Key Laboratory of Drug Targeting and Pharmacokinetic Evaluation, Wuhan 430030, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-0464
Outline
收藏切换

Metformin, as a first-line drug in the treatment of type 2 diabetes, is widely used in clinic with definite efficacy and few adverse reactions. In recent years, other effects besides hypoglycemia have been found, such as a possible therapeutic effect on mental disorders (e.g., anxiety disorder, Alzheimer's disease), cancer, and cardiovascular disease. It also has regulatory effects on intestinal microbiota. The purpose of this review is to summarize the recent investigations of metformin on mental disorders, cardiovascular diseases, cancer, and intestinal microbiota.

metformin  /  mental disorder  /  cardiovascular system  /  intestinal microbiota  /  neoplasm
肖文铉, 罗雅丹, 陈建国, 王芳. 二甲双胍的多效性研究进展. 药学学报, 2021 , 56 (12) : 3385 -3391 . DOI: 10.16438/j.0513-4870.2021-0464
Wen-xuan XIAO, Ya-dan LUO, Jian-guo CHEN, Fang WANG. Progress in the pleiotropic activity of metformin[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3385 -3391 . DOI: 10.16438/j.0513-4870.2021-0464
Appendix
Less
Year 2021 volume 56 Issue 12
978
502
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-0464
  • Receive Date：2021-03-30
  • Online Date：2025-12-18
  • Published：2021-12-12
Article Data
Affiliations
History
  • Received：2021-03-30
  • Revised：2021-04-29
Funding
Affiliations
    1. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    2. Hubei Key Laboratory of Drug Targeting and Pharmacokinetic Evaluation, Wuhan 430030, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-0464
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House