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Progress in the pleiotropic activity of metformin
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Wen-xuan XIAO1, Ya-dan LUO1, Jian-guo CHEN1, 2, Fang WANG1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3385 - 3391
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Acta Pharmaceutica Sinica | 2021, 56(12): 3385-3391
• Reviews •
Progress in the pleiotropic activity of metformin
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Wen-xuan XIAO1, Ya-dan LUO1, Jian-guo CHEN1, 2, Fang WANG1, 2, *
Affiliations
  • 1. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • 2. Hubei Key Laboratory of Drug Targeting and Pharmacokinetic Evaluation, Wuhan 430030, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-0464
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Metformin, as a first-line drug in the treatment of type 2 diabetes, is widely used in clinic with definite efficacy and few adverse reactions. In recent years, other effects besides hypoglycemia have been found, such as a possible therapeutic effect on mental disorders (e.g., anxiety disorder, Alzheimer's disease), cancer, and cardiovascular disease. It also has regulatory effects on intestinal microbiota. The purpose of this review is to summarize the recent investigations of metformin on mental disorders, cardiovascular diseases, cancer, and intestinal microbiota.

metformin  /  mental disorder  /  cardiovascular system  /  intestinal microbiota  /  neoplasm
Wen-xuan XIAO, Ya-dan LUO, Jian-guo CHEN, Fang WANG. Progress in the pleiotropic activity of metformin[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3385 -3391 . DOI: 10.16438/j.0513-4870.2021-0464
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Year 2021 volume 56 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2021-0464
  • Receive Date：2021-03-30
  • Online Date：2025-12-18
  • Published：2021-12-12
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History
  • Received：2021-03-30
  • Revised：2021-04-29
Funding
Affiliations
    1. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    2. Hubei Key Laboratory of Drug Targeting and Pharmacokinetic Evaluation, Wuhan 430030, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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