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A novel fatty acid monoglyceride from the stem and leaves of Ligusticum chuanxiong Hort.
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Hong-ling YAN1, Yao CHEN1, Fei TANG1, Jian FENG2, Chen-wan GUO1, Chang-jiang HU2, Jun LU1, *, Yu-zhu TAN1, *
Acta Pharmaceutica Sinica | 2021, 56(9) : 2573 - 2576
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Acta Pharmaceutica Sinica | 2021, 56(9): 2573-2576
• Original Articles •
A novel fatty acid monoglyceride from the stem and leaves of Ligusticum chuanxiong Hort.
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Hong-ling YAN1, Yao CHEN1, Fei TANG1, Jian FENG2, Chen-wan GUO1, Chang-jiang HU2, Jun LU1, *, Yu-zhu TAN1, *
Affiliations
  • 1. Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 2. Key Laboratory of Quality Control and Efficacy Evaluation of Traditional Chinese Medicine Formula Granules, Sichuan New Green Medicine Science and Technology Development Co., Ltd., Pengzhou 611930, China
Published: 2021-09-12 doi: 10.16438/j.0513-4870.2021-0377
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Two fatty acid monoglycerides were isolated from the petroleum ether fraction of the stem and leaves of Ligusticum chuanxiong by using MCI column, silica gel column, Sephadex LH-20 column and semi-preparative HPLC. Their structures were elucidated by 1D-NMR, 2D-NMR, HR-ESI-MS and optical rotation data. One of them is a new compound, named 14, 15-dehydrocrepenynic acid monoglyceride (1), the other was a known compound (R)-α-(7'Z, 10'Z, 13'Z)-hexadecatrienoic acid monoglyceride (2), both of which were isolated from Ligusticum chuanxiong for the first time. The results of in vitro antitumor activity assay showed that compounds 1 and 2 could inhibit the proliferation of MCF-7 with IC50 values of 30.75 and 36.82 μmol·L-1, respectively.

Ligusticum chuanxiong  /  stem and leaves  /  fatty acid monoglyceride  /  structure identification  /  antitumor activity
Hong-ling YAN, Yao CHEN, Fei TANG, Jian FENG, Chen-wan GUO, Chang-jiang HU, Jun LU, Yu-zhu TAN. A novel fatty acid monoglyceride from the stem and leaves of Ligusticum chuanxiong Hort.[J]. Acta Pharmaceutica Sinica, 2021 , 56 (9) : 2573 -2576 . DOI: 10.16438/j.0513-4870.2021-0377
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Article Info
doi: 10.16438/j.0513-4870.2021-0377
  • Receive Date：2021-03-17
  • Online Date：2025-12-18
  • Published：2021-09-12
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History
  • Received：2021-03-17
  • Revised：2021-04-12
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Affiliations
    1. Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    2. Key Laboratory of Quality Control and Efficacy Evaluation of Traditional Chinese Medicine Formula Granules, Sichuan New Green Medicine Science and Technology Development Co., Ltd., Pengzhou 611930, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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