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Paeoniae Rubra Radix decreases the hepatotoxicity of Psoraleae Fructus in an immunologically stressed rat model: a metabolic network analysis
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Wen-xing WU1, Sheng GUO1, *, Li-ping WU1, Ling XIA1, Ming ZHAO1, Quan LI2, Heng-bin WANG2, Jin-ao DUAN1, *
Acta Pharmaceutica Sinica | 2021, 56(7) : 1789 - 1796
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Acta Pharmaceutica Sinica | 2021, 56(7): 1789-1796
• Special Reports: Focalizing on the research of the quality control and in vivo process of natural drugs •
Paeoniae Rubra Radix decreases the hepatotoxicity of Psoraleae Fructus in an immunologically stressed rat model: a metabolic network analysis
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Wen-xing WU1, Sheng GUO1, *, Li-ping WU1, Ling XIA1, Ming ZHAO1, Quan LI2, Heng-bin WANG2, Jin-ao DUAN1, *
Affiliations
  • 1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Leiyunshang Pharmaceutical Co. Limited, Suzhou 215003, China
Published: 2021-07-12 doi: 10.16438/j.0513-4870.2021-0255
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An immunologically stressed rat model was used in a metabolomics study on the ability of Paeoniae Rubra Radix to reduce the liver toxicity of Psoraleae Fructus. Different groups of rats were given the extracts of Psoraleae Fructus and Psoraleae Fructus together with Paeoniae Rubra Radix or combined with a non-toxic dose of lipopolysaccharide (LPS). The biochemical indices of liver function and pathological changes in liver tissue were used to evaluate histopathological changes. UHPLC-QTOF/MS was used to analyze the metabolic profile of serum samples, combined with principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) methods. The HMDB database and Metabo Analyst online tool were used for biomarker identification and metabolic pathway-enrichment analysis. The results show that the co-treatment Psoraleae Fructus and LPS resulted in significant liver injury, indicated by the elevation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, as well as obvious pathological changes. Liver injury was significantly decreased by treatment with Paeoniae Rubra Radix. Metabolomic analysis showed that the addition of Paeoniae Rubra Radix ameliorated the abnormal serum metabolism in rats mainly through regulation of arachidonic acid metabolism and glycerophospholipid metabolism pathways.

Psoraleae Fructus  /  Paeoniae Rubra Radix  /  idiosyncratic hepatotoxicity  /  metabolomics
Wen-xing WU, Sheng GUO, Li-ping WU, Ling XIA, Ming ZHAO, Quan LI, Heng-bin WANG, Jin-ao DUAN. Paeoniae Rubra Radix decreases the hepatotoxicity of Psoraleae Fructus in an immunologically stressed rat model: a metabolic network analysis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (7) : 1789 -1796 . DOI: 10.16438/j.0513-4870.2021-0255
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Article Info
doi: 10.16438/j.0513-4870.2021-0255
  • Receive Date：2021-02-23
  • Online Date：2025-12-18
  • Published：2021-07-12
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History
  • Received：2021-02-23
  • Revised：2021-04-08
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Affiliations
    1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Leiyunshang Pharmaceutical Co. Limited, Suzhou 215003, China
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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