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Research and development progress of antibody drugs for idiopathic pulmonary fibrosis
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Yang MIAO, Xiao-he LI, Yun-qian ZHAI, Jia-kun BAI, Xiao-yang MA, Bu-ri XI, Jian-wei ZHANG, Hong-gang ZHOU*, Cheng YANG*
Acta Pharmaceutica Sinica | 2021, 56(11) : 2881 - 2886
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Acta Pharmaceutica Sinica | 2021, 56(11): 2881-2886
• Special Reports: Recent Advances in Visceral Organ Fibrosis and Antifibrotic Drug Discovery •
Research and development progress of antibody drugs for idiopathic pulmonary fibrosis
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Yang MIAO, Xiao-he LI, Yun-qian ZHAI, Jia-kun BAI, Xiao-yang MA, Bu-ri XI, Jian-wei ZHANG, Hong-gang ZHOU*, Cheng YANG*
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  • State Key Lab of Medicinal Chemical Biology, Tianjin Key Lab of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300350, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0247
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Idiopathic pulmonary fibrosis is a fibrous disease. At present, its pathogenesis has not been fully elucidated and there is no drug with definite therapeutic effect. After four stages of development, antibody drugs are becoming a new hotspot in drug research and development with their own advantages. A number of drugs have entered the stage of clinical trials. Based on this, this review summarizes the antibody drugs for the clinical stage of clinical research of idiopathic pulmonary fibrosis, in order to summarize the development of antibody drugs, and provide certain bases and ideas for the development of antibody drugs.

idiopathic pulmonary fibrosis  /  pathogenesis  /  antibody drug  /  target  /  clinical trial
Yang MIAO, Xiao-he LI, Yun-qian ZHAI, Jia-kun BAI, Xiao-yang MA, Bu-ri XI, Jian-wei ZHANG, Hong-gang ZHOU, Cheng YANG. Research and development progress of antibody drugs for idiopathic pulmonary fibrosis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 2881 -2886 . DOI: 10.16438/j.0513-4870.2021-0247
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Article Info
doi: 10.16438/j.0513-4870.2021-0247
  • Receive Date：2021-02-22
  • Online Date：2025-12-18
  • Published：2021-11-12
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  • Received：2021-02-22
  • Revised：2021-04-21
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    State Key Lab of Medicinal Chemical Biology, Tianjin Key Lab of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300350, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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