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Research advances on stimulator of interferon genes (STING) and its agonists
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Jia-jia CHANG1, Shi HOU2, Xin-lin YAN2, Jun-hai XIAO2, *
Acta Pharmaceutica Sinica | 2021, 56(7) : 1880 - 1892
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Acta Pharmaceutica Sinica | 2021, 56(7): 1880-1892
• Reviews •
Research advances on stimulator of interferon genes (STING) and its agonists
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Jia-jia CHANG1, Shi HOU2, Xin-lin YAN2, Jun-hai XIAO2, *
Affiliations
  • 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
  • 2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
Published: 2021-07-12 doi: 10.16438/j.0513-4870.2021-0223
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As a key signal transduction molecule involved in the innate immune response, stimulator of interferon genes (STING) is triggered by cytosolic DNA from pathogen and host origins, and plays an important role in inducing the secretion of type Ⅰ interferons and proinflammatory cytokines, thereby defending against viral and intracellular bacterial infections and regulating the production of spontaneous antitumor immune responses in vivo. Thus, STING agonists have shown useful therapeutic effects for pathogen infection and cancer. In the past decade research on STING and its agonists has progressed rapidly. Here, we summarize recent advances in the structure and activation of STING and the mechanism of the cGAS-STING pathway. In particular, we review research advances of STING agonists, analyze the crystal structure of STING in complex with its agonists and the structure-activity relationship of STING agonists, and summarize the strong challenges of developing STING agonists.

stimulator of interferon genes  /  cGAS-STING pathway  /  STING agonist  /  crystal structure  /  structure-activity relationship
Jia-jia CHANG, Shi HOU, Xin-lin YAN, Jun-hai XIAO. Research advances on stimulator of interferon genes (STING) and its agonists[J]. Acta Pharmaceutica Sinica, 2021 , 56 (7) : 1880 -1892 . DOI: 10.16438/j.0513-4870.2021-0223
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Year 2021 volume 56 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2021-0223
  • Receive Date：2021-02-08
  • Online Date：2025-12-18
  • Published：2021-07-12
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  • Received：2021-02-08
  • Revised：2021-03-02
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Affiliations
    1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
    2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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