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Effects of temperature, pH, and H2O2 on the growth and biofilm formation of attenuated Salmonella VNP20009
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Jing LI1, Fei-fei BAO1, Jia-huang LI1, 2, 3, *, Zi-chun HUA1, 2, 3, *
Acta Pharmaceutica Sinica | 2021, 56(6) : 1606 - 1611
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Acta Pharmaceutica Sinica | 2021, 56(6): 1606-1611
• Original Articles •
Effects of temperature, pH, and H2O2 on the growth and biofilm formation of attenuated Salmonella VNP20009
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Jing LI1, Fei-fei BAO1, Jia-huang LI1, 2, 3, *, Zi-chun HUA1, 2, 3, *
Affiliations
  • 1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
  • 2. College of Biopharmaceuticals, China Pharmaceutical University, Nanjing 211198, China
  • 3. High-Tech Research Institute of Nanjing University at Changzhou and Jiangsu Target Pharma Laboratories Inc., Changzhou 213164, China
Published: 2021-06-12 doi: 10.16438/j.0513-4870.2021-0175
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Attenuated Salmonella VNP20009 specifically colonizes and proliferates within tumor tissues and inhibits tumor growth. It has been used as drug delivery vehicle or in combination with other therapies (such as chemotherapy), which shows a good application potential in tumor therapy. In this paper, study was conducted to determine the physiological changes of growth curve and formation of bacterial biofilm of VNP20009 under various environmental stresses, such as temperature, pH, and H2O2. The results showed that VNP20009 could grow normally under the conditions of 42 ℃, pH 6.5, and 1 mmol·L-1 H2O2. Furthermore, the weak acid environment was beneficial to the biofilm formation of VNP20009. This study provides a basis for in-depth study of the survival mechanism and application of attenuated Salmonella.

Salmonella  /  VNP20009  /  growth  /  biofilm  /  microbiological phenomena
Jing LI, Fei-fei BAO, Jia-huang LI, Zi-chun HUA. Effects of temperature, pH, and H2O2 on the growth and biofilm formation of attenuated Salmonella VNP20009[J]. Acta Pharmaceutica Sinica, 2021 , 56 (6) : 1606 -1611 . DOI: 10.16438/j.0513-4870.2021-0175
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Article Info
doi: 10.16438/j.0513-4870.2021-0175
  • Receive Date：2021-01-31
  • Online Date：2025-12-18
  • Published：2021-06-12
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History
  • Received：2021-01-31
  • Revised：2021-02-24
Funding
Affiliations
    1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
    2. College of Biopharmaceuticals, China Pharmaceutical University, Nanjing 211198, China
    3. High-Tech Research Institute of Nanjing University at Changzhou and Jiangsu Target Pharma Laboratories Inc., Changzhou 213164, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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