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A new dimeric dehydrocorydaline alkaloid from vinegar-prepared Corydalis yanhusuo
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Dong-jie FANG1, Gui-yang XIA2, *, Ling-yan WANG1, Huan XIA2, Yan-bin SUN1, Sheng LIN1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(4) : 1096 - 1099
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Acta Pharmaceutica Sinica | 2021, 56(4): 1096-1099
• Original Articles •
A new dimeric dehydrocorydaline alkaloid from vinegar-prepared Corydalis yanhusuo
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Dong-jie FANG1, Gui-yang XIA2, *, Ling-yan WANG1, Huan XIA2, Yan-bin SUN1, Sheng LIN1, 2, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Published: 2021-04-12 doi: 10.16438/j.0513-4870.2021-0121
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Bidehydrocorydaline A (1), a new dimeric alkaloid of proberberine connected by a methylenedioxy group, was isolated from the vinegar-prepared Corydalis yanhusuo by various chromatographic methods, including column chromatography over macroporous adsorption resin and silica gel, reverse-phase MPLC, and semi-preparative HPLC. Its structure was determined by spectroscopic methods, including UV, IR, HR-ESI-MS, 1D and 2D NMR. Bidehydrocorydaline A (1) showed potent inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages, with an IC50 value of 2.33 ±0.57 μmol·L-1.

Corydalis yanhusuo  /  dimeric alkaloid  /  protoberberine  /  anti-inflammatory
Dong-jie FANG, Gui-yang XIA, Ling-yan WANG, Huan XIA, Yan-bin SUN, Sheng LIN. A new dimeric dehydrocorydaline alkaloid from vinegar-prepared Corydalis yanhusuo[J]. Acta Pharmaceutica Sinica, 2021 , 56 (4) : 1096 -1099 . DOI: 10.16438/j.0513-4870.2021-0121
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Article Info
doi: 10.16438/j.0513-4870.2021-0121
  • Receive Date：2021-01-22
  • Online Date：2025-12-18
  • Published：2021-04-12
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History
  • Received：2021-01-22
  • Revised：2021-02-07
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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