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Application and mechanism of nanomedicine in antifungal infection therapy
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Shui-sheng CHEN1, Ke-qian ZHOU2, Xiao-dong LI1, Quan-zhen LÜ1, Yuan YU1, *
Acta Pharmaceutica Sinica | 2021, 56(7) : 1893 - 1901
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Acta Pharmaceutica Sinica | 2021, 56(7): 1893-1901
• Reviews •
Application and mechanism of nanomedicine in antifungal infection therapy
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Shui-sheng CHEN1, Ke-qian ZHOU2, Xiao-dong LI1, Quan-zhen LÜ1, Yuan YU1, *
Affiliations
  • 1. School of Pharmacy, Naval Medical University, Shanghai 200433, China
  • 2. Anesthesiology Department, Naval Medical University, Shanghai 200433, China
Published: 2021-07-12 doi: 10.16438/j.0513-4870.2021-0053
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The threat of fungal diseases is increasingly rigorous. The clinically invasive fungal infections remain a main cause of morbidity and mortality in certain high-risk groups, especially in critical patients or immunocompromised patients. In drug therapy, the problems of off-target toxicity and antifungal drug resistance are still challenging. With the wide application of biomaterials and nanotechnology, more nanomedicine studies have been carried out on antifungal drugs, such as the amphotericin B liposome which greatly reduced the renal toxicity of drugs has been successfully marketed. For the unique physical and chemical properties, the nano-drug delivery system possessed great potential in improving the bioavailability, reducing the side effects of drugs, increasing the stability of drugs, and achieving cells or tissue-specificity through the modification. This review summarized the applications and limitations of antifungal drugs. Some nanomedicines were summarized in discussion oriented around the antifungal therapy, including liposomes, niosomes, lipid nanoparticles, polymer nanoparticles, microemulsion, dendrimers, inorganic nanocarriers. Nanotechnology and nano-drug delivery system provide promising strategies for the research and development of new formulations that can improve antifungal activity and possibly overcome antifungal drug resistance.

fungal disease  /  antifungal agent  /  drug resistance  /  nanomedicine  /  biomaterial
Shui-sheng CHEN, Ke-qian ZHOU, Xiao-dong LI, Quan-zhen LÜ, Yuan YU. Application and mechanism of nanomedicine in antifungal infection therapy[J]. Acta Pharmaceutica Sinica, 2021 , 56 (7) : 1893 -1901 . DOI: 10.16438/j.0513-4870.2021-0053
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Article Info
doi: 10.16438/j.0513-4870.2021-0053
  • Receive Date：2021-01-12
  • Online Date：2025-12-18
  • Published：2021-07-12
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  • Received：2021-01-12
  • Revised：2021-02-25
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Affiliations
    1. School of Pharmacy, Naval Medical University, Shanghai 200433, China
    2. Anesthesiology Department, Naval Medical University, Shanghai 200433, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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