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Analysis of triterpenoic acids in different medicinal parts of Poria cocos (Schw.) Wolf using supercritical fluid chromatography
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Na LI1, 2, Yuan-gui YANG1, Yue CHEN1, Rui XU1, Li-hua GU1, Yuan-biao XIE3, Song-ming LI3, Chang-sen ZHAN3, Zheng-tao WANG1, Li YANG1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(4) : 1120 - 1126
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Acta Pharmaceutica Sinica | 2021, 56(4): 1120-1126
• Original Articles •
Analysis of triterpenoic acids in different medicinal parts of Poria cocos (Schw.) Wolf using supercritical fluid chromatography
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Na LI1, 2, Yuan-gui YANG1, Yue CHEN1, Rui XU1, Li-hua GU1, Yuan-biao XIE3, Song-ming LI3, Chang-sen ZHAN3, Zheng-tao WANG1, Li YANG1, 2, *
Affiliations
  • 1. The MOE Key Laboratory for Standardization of Chinese Medicines and SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 3. Shanghai Hutchison Pharmaceuticals Co., Ltd., Shanghai 201401, China
Published: 2021-04-12 doi: 10.16438/j.0513-4870.2021-0045
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Qualitative and quantitative methods were used to establish the quality of different medicinal parts of Poria cocos (Poriae Cutis, rubra Poria, white Poria, Poria cum Radix Pini) by using ultra-performance convergence chromatography coupled with photo-diode array and quadrupole time-of-flight mass spectrometry (UPC2-PDA-Q-TOF/MSE). A total of 18 chromatographic peaks were detected from Poria cocos by UPC2-PDA. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to compare the four medicinal parts. The results showed that there were significant differences in the components of different medicinal parts, and the main triterpenoic acids were poricoic acid A, poricoic acid B, dehydroeburicoic acid, and dehydrotrametenolic acid. When combined with the common active component polyporenic acid C, a method for determination of five triterpenoic acids in different parts of Poria cocos was established. These components could be separated within 15 min, and the amount of methanol was 3.63% of that of HPLC method. Taking the five triterpenoid acids as an index, the content of triterpenoid acids in different parts of Poria cocos from high to low were Poriae Cutis, rubra Poria, white Poria and Poria cum Radix Pini. The method is simple, rapid, and uses minimal solvent. The mobile phase of environment-friendly gas carbon dioxide has unique advantages in reducing environmental pollution, which can provide a basis for the development and standard formulation of Poria cocos and its related products.

Poria cocos  /  different medicinal part  /  triterpenoid acid  /  ultra-performance convergence chromatography  /  assay determination
Na LI, Yuan-gui YANG, Yue CHEN, Rui XU, Li-hua GU, Yuan-biao XIE, Song-ming LI, Chang-sen ZHAN, Zheng-tao WANG, Li YANG. Analysis of triterpenoic acids in different medicinal parts of Poria cocos (Schw.) Wolf using supercritical fluid chromatography[J]. Acta Pharmaceutica Sinica, 2021 , 56 (4) : 1120 -1126 . DOI: 10.16438/j.0513-4870.2021-0045
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Article Info
doi: 10.16438/j.0513-4870.2021-0045
  • Receive Date：2021-01-08
  • Online Date：2025-12-18
  • Published：2021-04-12
Article Data
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History
  • Received：2021-01-08
  • Revised：2021-02-23
Funding
Affiliations
    1. The MOE Key Laboratory for Standardization of Chinese Medicines and SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    3. Shanghai Hutchison Pharmaceuticals Co., Ltd., Shanghai 201401, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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