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Research progress on STAT protein inhibitors in the treatment of lymphoma
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Qi-hong DENG1, Zheng WANG2, Xian-ming DENG1, Li LI1, *
Acta Pharmaceutica Sinica | 2021, 56(3) : 703 - 710
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Acta Pharmaceutica Sinica | 2021, 56(3): 703-710
• Reviews •
Research progress on STAT protein inhibitors in the treatment of lymphoma
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Qi-hong DENG1, Zheng WANG2, Xian-ming DENG1, Li LI1, *
Affiliations
  • 1. State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen 361102, China
  • 2. College of Food and Biological Engineering, Jimei University, Xiamen 361021, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1831
Outline
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The abnormal activation and mutation of signal transducer and activator transcription (STAT) proteins has been implicated in multiple lymphomas. The research discovery and clinical application of STATs inhibitors have become an important strategy for treating lymphoma. This review introduces the abnormal activation and mutation of STATs in multiple malignant lymphomas, and focuses on reviewing the latest screening strategies targeting STATs and its clinical application in the treatment of lymphoma, providing references for the further development of STATs inhibitors.

lymphoma  /  STAT transcription factor  /  antineoplastic agent  /  drug screening  /  targeted therapy
Qi-hong DENG, Zheng WANG, Xian-ming DENG, Li LI. Research progress on STAT protein inhibitors in the treatment of lymphoma[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 703 -710 . DOI: 10.16438/j.0513-4870.2020-1831
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Article Info
doi: 10.16438/j.0513-4870.2020-1831
  • Receive Date：2020-12-01
  • Online Date：2025-12-18
  • Published：2021-03-12
Article Data
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History
  • Received：2020-12-01
  • Revised：2020-12-25
Funding
Affiliations
    1. State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen 361102, China
    2. College of Food and Biological Engineering, Jimei University, Xiamen 361021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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