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Research progress of aristolochic acids and their biomarkers
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Ning GUO1, 2, Yong ZHAO1, Yi SUN1, *, An-qi WANG1, Ling-chuan XU2, Ai-hua LIANG1, *
Acta Pharmaceutica Sinica | 2021, 56(4) : 972 - 982
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Acta Pharmaceutica Sinica | 2021, 56(4): 972-982
• Reviews •
Research progress of aristolochic acids and their biomarkers
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Ning GUO1, 2, Yong ZHAO1, Yi SUN1, *, An-qi WANG1, Ling-chuan XU2, Ai-hua LIANG1, *
Affiliations
  • 1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
Published: 2021-04-12 doi: 10.16438/j.0513-4870.2020-1719
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Aristolochic acids (AAs) are widely distributed in Aristolochiaceae, and are important toxic components in medicinal plants of Aristolochiaceae. As one of the most powerful carcinogens in the Carcinogenic Potency Database (CPDB), AAs can induce hepatotoxicity, nephrotoxicity, carcinogenicity, mutagenicity, and other adverse reaction. AAs also can produce a series of metabolites such as AA-DNA adducts in the body, and their specific metabolites can be used as biomarkers for early diagnosis and treatment of related diseases. Thus, the current discovery for technical means that can quickly and accurately detect biomarkers possesses significant research value. AAs can be attenuated by processing, compatibility, molecular breeding, and other methods to improve the clinical safety of Chinese medicine containing AAs. In this review, we report the distribution of AAs, attenuation strategies and biomarker detection. We would like to provide a reference for the quality control of AAs-containing Chinese medicines, as well as for the prevention and control of diseases caused by AAs.

aristolochic acid  /  toxicity  /  biomarker  /  attenuation
Ning GUO, Yong ZHAO, Yi SUN, An-qi WANG, Ling-chuan XU, Ai-hua LIANG. Research progress of aristolochic acids and their biomarkers[J]. Acta Pharmaceutica Sinica, 2021 , 56 (4) : 972 -982 . DOI: 10.16438/j.0513-4870.2020-1719
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Article Info
doi: 10.16438/j.0513-4870.2020-1719
  • Receive Date：2020-11-05
  • Online Date：2025-12-18
  • Published：2021-04-12
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History
  • Received：2020-11-05
  • Revised：2021-01-06
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Affiliations
    1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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