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Advances of Lefamulin: a new pleuromutilin antibiotic
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Xue-yao LI1, Ji-shun LI1, 3, Zi-hao ZHU1, Tao-ting-yue LI2, Wen-xuan ZHANG1, Jie XIA1, Tian-lei LI1, *, Song WU1, *
Acta Pharmaceutica Sinica | 2021, 56(4) : 1006 - 1015
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Acta Pharmaceutica Sinica | 2021, 56(4): 1006-1015
• Reviews •
Advances of Lefamulin: a new pleuromutilin antibiotic
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Xue-yao LI1, Ji-shun LI1, 3, Zi-hao ZHU1, Tao-ting-yue LI2, Wen-xuan ZHANG1, Jie XIA1, Tian-lei LI1, *, Song WU1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medical, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Beijing No. 161 High School, Beijing 100020, China
  • 3. Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China
Published: 2021-04-12 doi: 10.16438/j.0513-4870.2020-1617
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Lefamulin (BC-3781) is a semi-synthetic pleuromutilin antibiotic, approved for the treatment of community-acquired bacterial pneumonia (CABP) by Food and Drug Administration (USA) in August 2019, with the commodity name of Xenleta. It is the first pleuromutilin antibiotics used for systemic treatment of bacterial infections in human. Lefamulin binds to the peptidyl transferase center of the 50S ribosomal subunit to prevent peptide transfer, thus inhibits protein synthesis. Lefamulin displays expanded activity against gram-positive organisms, and also shows high activity against atypical microorganism like Mycoplasma pneumoniae. This review discusses the mechanism, bacterial spectrum of activity, preclinical and clinical data of Lefamulin.

pleuromutilin  /  Lefamulin  /  antibacterial activity  /  community-acquired bacterial pneumonia
Xue-yao LI, Ji-shun LI, Zi-hao ZHU, Tao-ting-yue LI, Wen-xuan ZHANG, Jie XIA, Tian-lei LI, Song WU. Advances of Lefamulin: a new pleuromutilin antibiotic[J]. Acta Pharmaceutica Sinica, 2021 , 56 (4) : 1006 -1015 . DOI: 10.16438/j.0513-4870.2020-1617
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Article Info
doi: 10.16438/j.0513-4870.2020-1617
  • Receive Date：2020-10-16
  • Online Date：2025-12-18
  • Published：2021-04-12
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History
  • Received：2020-10-16
  • Revised：2020-11-17
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medical, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Beijing No. 161 High School, Beijing 100020, China
    3. Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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