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Safety and effectiveness of hemoperfusion on the removal of uremic toxins in chronic kidney disease
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Meng-yao AN1, 2, Peng GE2, Lei HU2, Fei ZHONG2, Bo-yu ZHOU2, Chang-xiao LIU1, 2, 3, *
Acta Pharmaceutica Sinica | 2020, 55(12) : 2924 - 2933
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Acta Pharmaceutica Sinica | 2020, 55(12): 2924-2933
• Original Articles •
Safety and effectiveness of hemoperfusion on the removal of uremic toxins in chronic kidney disease
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Meng-yao AN1, 2, Peng GE2, Lei HU2, Fei ZHONG2, Bo-yu ZHOU2, Chang-xiao LIU1, 2, 3, *
Affiliations
  • 1. Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
  • 2. Tianjin Tiancheng New Drug Evaluation Research Co., Ltd., Tianjin 300301, China
  • 3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
Published: 2020-12-12 doi: 10.16438/j.0513-4870.2020-1533
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The goal of the present study was to determine the effectiveness and safety of hemoperfusion (HP) in beagle dogs with chronic kidney disease (CKD). The experimental protocol was approved by the Institutional Animal Care and Use Committee of Tianjin Institute of Pharmaceutical Research New Drug Evaluation Research (IACUC2019071501). Twelve CKD model beagles were randomly divided into two groups: a low-frequency treatment group (n=6) and a high-frequency treatment group (n=6). The dogs in the high- and low-frequency groups received HP treatment every 3 days and once per week, respectively, for two treatments, with each session lasting 2 h. The test results showed that high-frequency HP treatment significantly decreased the accumulation of toxins in the CKD beagles. Hematology, coagulation function, electrolytes and liver function indicated that the HP treatment was safe. The body index effects were consistent between the low- and high-frequency treatment groups. Therefore, HP treatment once every 3 days was safe at the animal level. Multiple HP treatments every 3 days were more conducive than weekly treatments to the removal of uremic toxins with better prognosis and had no associated safety hazards.

chronic kidney disease  /  beagle dog  /  uremic toxin  /  hemoperfusion  /  blood purification
Meng-yao AN, Peng GE, Lei HU, Fei ZHONG, Bo-yu ZHOU, Chang-xiao LIU. Safety and effectiveness of hemoperfusion on the removal of uremic toxins in chronic kidney disease[J]. Acta Pharmaceutica Sinica, 2020 , 55 (12) : 2924 -2933 . DOI: 10.16438/j.0513-4870.2020-1533
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Article Info
doi: 10.16438/j.0513-4870.2020-1533
  • Receive Date：2020-09-24
  • Online Date：2026-01-23
  • Published：2020-12-12
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History
  • Received：2020-09-24
  • Revised：2020-10-16
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Affiliations
    1. Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    2. Tianjin Tiancheng New Drug Evaluation Research Co., Ltd., Tianjin 300301, China
    3. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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