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Research progress on indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors
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Ting WANG, Hui WEN, Hua-qing CUI*, Da-li YIN
Acta Pharmaceutica Sinica | 2021, 56(3) : 723 - 733
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Acta Pharmaceutica Sinica | 2021, 56(3): 723-733
• Reviews •
Research progress on indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors
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Ting WANG, Hui WEN, Hua-qing CUI*, Da-li YIN
Affiliations
  • Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1421
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Indoleamine 2, 3-dioxygenase 1 (IDO1) is the rate-limiting enzyme in the degradation of tryptophan to kynurenine. IDO1 is highly expressed in some tumor tissues. IDO1 can deplete tryptophan in tumor microenvironment, inhibit T cell function, and mediate the immune escape of tumor cells. Thus, IDO1 is considered a potential target of tumor immunotherapy. Currently, there are several IDO1 inhibitors in clinical research studies. The mechanism of IDO1-mediated tumor immune escape and the structure of IDO1 inhibitors are summarized in this review.

indoleamine 2, 3-dioxygenase 1  /  tryptophan  /  tumor  /  immune escape  /  IDO1 inhibitor
Ting WANG, Hui WEN, Hua-qing CUI, Da-li YIN. Research progress on indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 723 -733 . DOI: 10.16438/j.0513-4870.2020-1421
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Article Info
doi: 10.16438/j.0513-4870.2020-1421
  • Receive Date：2020-08-28
  • Online Date：2025-12-18
  • Published：2021-03-12
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  • Received：2020-08-28
  • Revised：2020-09-23
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    Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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