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New use of an old drug: advances in antiviral effect of chloroquine in vivo and in vitro
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Hui WANG1, Long-cai TONG1, Rong LI1, 2, Guang WU1, Yu-sheng ZHOU2, 3, *
Acta Pharmaceutica Sinica | 2020, 55(6) : 1125 - 1136
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Acta Pharmaceutica Sinica | 2020, 55(6): 1125-1136
• Reviews •
New use of an old drug: advances in antiviral effect of chloroquine in vivo and in vitro
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Hui WANG1, Long-cai TONG1, Rong LI1, 2, Guang WU1, Yu-sheng ZHOU2, 3, *
Affiliations
  • 1. The Second Affiliated Hospital, University of South China, Hengyang 421001, China
  • 2. Institute of Pharmaceutical Pharmacology, University of South China, Hengyang 421001, China
  • 3. The Affiliated Nanhua Hospital, University of South China, Hengyang 421001, China
Published: 2020-06-12 doi: 10.16438/j.0513-4870.2020-0430
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Chloroquine is a quinine derivative which is synthesized by German scholars in 1934. In addition to its anti-malaria, treatment of systemic lupus erythematosus and immunomodulatory effects, chloroquine is also found valuable in broad-spectrum antiviral treatment. Clinical trials have confirmed that chloroquine has a good effect on acquired immunodeficiency syndrome. In 2019, there were many patients infected with novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2). Preliminary clinical trials showed that chloroquine had obvious curative effect on patients with SARS-CoV-2. We summarize the effects of chloroquine to different viruses, explain its mechanism, and compare the results of its experiments in vitro and in vivo. The antiviral effect of chloroquine in vivo and in vitro are not consistent, which may be related to the model of animal, dosage and distribution of chloroquine in vivo, and the design of clinical research.

chloroquine  /  antiviral agent  /  cell proliferation  /  animal experimentation  /  clinical trial
Hui WANG, Long-cai TONG, Rong LI, Guang WU, Yu-sheng ZHOU. New use of an old drug: advances in antiviral effect of chloroquine in vivo and in vitro[J]. Acta Pharmaceutica Sinica, 2020 , 55 (6) : 1125 -1136 . DOI: 10.16438/j.0513-4870.2020-0430
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Year 2020 volume 55 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2020-0430
  • Receive Date：2020-03-30
  • Online Date：2026-01-21
  • Published：2020-06-12
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  • Received：2020-03-30
  • Revised：2020-04-27
Funding
Affiliations
    1. The Second Affiliated Hospital, University of South China, Hengyang 421001, China
    2. Institute of Pharmaceutical Pharmacology, University of South China, Hengyang 421001, China
    3. The Affiliated Nanhua Hospital, University of South China, Hengyang 421001, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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