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Advances in research on the pharmacological effects and mechanism of action of chlorogenic acid
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Qing-hua WANG, Ting-ting DU, Zhi-hui ZHANG, Ming JI, Hai-yu HU, Xiao-guang CHEN*
Acta Pharmaceutica Sinica | 2020, 55(10) : 2273 - 2280
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Acta Pharmaceutica Sinica | 2020, 55(10): 2273-2280
• Reviews •
Advances in research on the pharmacological effects and mechanism of action of chlorogenic acid
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Qing-hua WANG, Ting-ting DU, Zhi-hui ZHANG, Ming JI, Hai-yu HU, Xiao-guang CHEN*
Affiliations
  • Small-molecule Immuno-oncology Drug Discovery Key Laboratory of Chinese Academy of Medical Sciences, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2020-10-12 doi: 10.16438/j.0513-4870.2020-0423
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In recent years, with rapid advances in chlorogenic acid (CGA) research, it has become widely used in medicine, the chemical industry and health care products, with the potential for broad application. CGA is a water-soluble phenolic natural product and is extensively distributed in a variety of plants. Numerous studies have shown that CGA has strong biological activities including antibacterial, antiviral, antitumor, antioxidative, anti-inflammatory and metabolic regulatory activities. This review summarizes the pharmacological effects as well as the underlying mechanisms of CGA, providing an important theoretical basis for further research on CGA drug targets and potential mechanisms.

chlorogenic acid  /  antibacterial activity  /  antiviral activity  /  antitumor activity  /  antioxidative activity  /  anti-inflammatory activity  /  metabolic regulatory activity  /  mechanism
Qing-hua WANG, Ting-ting DU, Zhi-hui ZHANG, Ming JI, Hai-yu HU, Xiao-guang CHEN. Advances in research on the pharmacological effects and mechanism of action of chlorogenic acid[J]. Acta Pharmaceutica Sinica, 2020 , 55 (10) : 2273 -2280 . DOI: 10.16438/j.0513-4870.2020-0423
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Year 2020 volume 55 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2020-0423
  • Receive Date：2020-03-27
  • Online Date：2026-01-23
  • Published：2020-10-12
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  • Received：2020-03-27
  • Revised：2020-04-29
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    Small-molecule Immuno-oncology Drug Discovery Key Laboratory of Chinese Academy of Medical Sciences, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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