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Advances in anti-tumor drug research based on reactive oxygen regulation
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Yi MOU1, Shuai WEN1, Xin-xing GAO1, Rui ZHANG1, Yan WANG1, Zheng-yu JIANG2, *
Acta Pharmaceutica Sinica | 2020, 55(7) : 1453 - 1465
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Acta Pharmaceutica Sinica | 2020, 55(7): 1453-1465
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Advances in anti-tumor drug research based on reactive oxygen regulation
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Yi MOU1, Shuai WEN1, Xin-xing GAO1, Rui ZHANG1, Yan WANG1, Zheng-yu JIANG2, *
Affiliations
  • 1. College of Pharmacy and Chemistry and Chemical Engineering, Taizhou University, Taizhou 225300, China
  • 2. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Published: 2020-07-12 doi: 10.16438/j.0513-4870.2020-0281
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Reactive oxygen species (ROS) which were partial metabolites of oxygen are highly reactive. Different concentrations of ROS have different effects on tumor development. Tumor cells have a high level of reactive oxygen species. The antioxidant system of tumor is in highly activated state, and thus modulation of reactive oxygen species levels could be an effective strategy to target cancer cells. Treatment with small molecules that disrupt the redox balance can kill tumor cells first. This paper outlines the main ideas of developing anti-tumor drugs based on reactive oxygen species regulation, and summarizes the representative drugs and research progress according to the mechanism of action, in an effort to suggest potential reference and ideas for developing antitumor drugs based on reactive oxygen species regulation.

reactive oxygen species  /  cancer chemotherapy  /  redox balance  /  glutathione  /  Nrf2
Yi MOU, Shuai WEN, Xin-xing GAO, Rui ZHANG, Yan WANG, Zheng-yu JIANG. Advances in anti-tumor drug research based on reactive oxygen regulation[J]. Acta Pharmaceutica Sinica, 2020 , 55 (7) : 1453 -1465 . DOI: 10.16438/j.0513-4870.2020-0281
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Article Info
doi: 10.16438/j.0513-4870.2020-0281
  • Receive Date：2020-03-10
  • Online Date：2026-01-21
  • Published：2020-07-12
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History
  • Received：2020-03-10
  • Accepted：2020-04-04
Funding
Affiliations
    1. College of Pharmacy and Chemistry and Chemical Engineering, Taizhou University, Taizhou 225300, China
    2. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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